Abstract

Experimental and clinical studies provided evidence that astrocytes are inherent components of neural networks. Astrocytes can affect synaptic processes by modulating the activity of neuro- and gliotransmitters. The role of the microglia in the organization of network spaces and the formation of neuroastrocytic domains is considered one of the leading mechanisms of memory and cognitive function. A disorder at the level of synaptic transmission results in the impairment of these processes. For the first time, we present the mechanism by which astrocytes, as components of synaptic processes, become involved in neuropsychic diseases.

中文翻译：

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脑星形胶质细胞和突触失调：神经变性和精神病理学。

摘要

实验和临床研究提供了证据，表明星形胶质细胞是神经网络的固有组成部分。星形胶质细胞可通过调节神经递质和神经胶质递质的活性来影响突触过程。小胶质细胞在网络空间的组织和神经星形细胞域的形成中的作用被认为是记忆和认知功能的主要机制之一。突触传递水平的障碍导致这些过程的损害。首次，我们介绍了星形胶质细胞作为突触过程的组成部分参与神经精神疾病的机制。