The study examined the effect of BSA on cultured cells of breast cancer, erythroleukemia, and ovarian carcinoma. BSA cytotoxic activity was examined with light microscopy and spectrophotometry in the concentration range of 6.25 to 50 mg/ml. The high concentrations of BSA disrupted the tumor cells in parallel with formation of vesicular debris. The destruction parameters were similar in diverse types of cells: BSA (50 mg/ml) disrupted 75.5±0.7% breast cancer cells, 75.8±0.2% erythroleukemia cells, and 78.8±0.1% cells of ovarian carcinoma (p≥0.05). The effect of BSA was dose-dependent in each type of cells. The data attest that BSA can disrupt various tumor cells in vitro.

中文翻译：

---

白蛋白对体外肿瘤细胞的影响

该研究检查了 BSA 对培养的乳腺癌、红白血病和卵巢癌细胞的影响。用光学显微镜和分光光度法在 6.25 至 50 mg/ml 的浓度范围内检查 BSA 细胞毒活性。高浓度的 BSA 在形成囊泡碎片的同时破坏了肿瘤细胞。不同类型细胞的破坏参数相似：BSA (50 mg/ml) 破坏了 75.5±0.7% 的乳腺癌细胞、75.8±0.2% 的红白血病细胞和 78.8±0.1% 的卵巢癌细胞 (p≥0.05)。BSA 的作用在每种类型的细胞中都是剂量依赖性的。数据证明BSA可以在体外破坏各种肿瘤细胞。