For studying the possibility of using catheter denervation of the pulmonary artery for the treatment of pulmonary hypertension, large animals, such as pigs, are more suitable, because the diameter of the pulmonary artery in this case allows manipulation of the ablation catheter. The study of the perivascular adipose tissue of the trunk and bifurcation of the pulmonary artery in humans and pigs revealed differences in the density and diameter of nerve fibers, but their depth did not differ. Immunohistochemical analysis with different markers of the autonomic nervous system receptors revealed similar receptor profile in human and pigs, though the expression of all studied markers in pigs was less pronounced than in humans. These findings attest to similarity of the innervation of the pulmonary arteries in humans and pigs under normal conditions.

中文翻译：

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人和猪肺动脉的血管周围神经支配：开发去神经支配实验模型的比较研究

为了研究使用肺动脉导管去神经支配治疗肺动脉高压的可能性，大型动物（如猪）更适合，因为在这种情况下肺动脉的直径允许操作消融导管。对人和猪的躯干和肺动脉分叉处血管周围脂肪组织的研究揭示了神经纤维的密度和直径存在差异，但它们的深度没有差异。用自主神经系统受体的不同标记物进行免疫组织化学分析显示，人和猪的受体谱相似，尽管所有研究的标记物在猪中的表达不如在人类中明显。这些发现证明了在正常条件下人和猪的肺动脉神经支配的相似性。