This article describes models for the study of acute desynchronosis: jetlag syndrome and acute desynchronosis under physical stress for possible pharmacological correction of these disorders. The cosinor analysis allowed assessing significance of changes in biological rhythms in 2 biological models: the jetlag-type diurnal rhythm shift model and the model with changed light mode. The revealed changes in the rhythms of biochemical parameters in the blood serum of animals with acute desynchronosis indicate significant changes in the intensity of carbohydrate-lipid metabolism, which affected the processes of cell bioenergetics. These changes are most pronounced in the group of animals that were kept under conditions of constant darkness, which can serve as a marker of the initial stage of pathological desynchronosis. The jetlag-type model can be used to evaluate the effectiveness of the pharmacological correction of physiological desynchronosis. The model with modified light regimen can be used for evaluation of the effectiveness of pharmacological correction of pathological desynchronosis.

中文翻译：

---

急性失同步模型动物生化参数生物节律的变化

本文介绍了研究急性失步症的模型：时差综合征和身体压力下的急性失步症，以便对这些疾病进行可能的药理学矫正。余弦分析允许评估 2 个生物模型中生物节律变化的显着性：时差型昼夜节律偏移模型和光模式改变的模型。急性失同步动物血清中生化参数节律的变化表明碳水化合物-脂质代谢强度的显着变化，这影响了细胞生物能量学的过程。这些变化在保持在持续黑暗条件下的动物组中最为明显，这可以作为病理失同步初始阶段的标志。时差型模型可用于评估生理失步的药理矫正效果。改良光照方案的模型可用于评估病理失同步的药理矫正效果。