We evaluated the protective effect of ademetionine, cytoflavin, and dihydroquercetin on activity of serum enzymes in rats treated with high doses of sodium valproate for 28 days. Ademetionine and cytoflavin produced the greatest protective effect, the effect of dihydroquercetin was less pronounced. In rats treated with ademetionine, AST activity decreased as soon as on day 7 and remained at this level until the end of the experiment; ALT, alkaline phosphatase, and γ-glutamyl transferase activities decreased on days 21 and 28 of the study. Cytoflavin produced similar effects, the effect of dihydroquercetin was observed on days 21 and 28 for AST, ALT, alkaline phosphatase and on day 28 for γ-glutamyl transferase. These results substantiate the use of hepatoprotective drugs in case of long-term treatment with anticonvulsants in patients with epilepsy.

中文翻译：

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腺苷蛋氨酸、细胞黄素和二氢槲皮素对高剂量丙戊酸钠治疗大鼠血酶活性保护作用的评价

我们评估了腺苷蛋氨酸、细胞黄素和二氢槲皮素对用高剂量丙戊酸钠治疗 28 天的大鼠血清酶活性的保护作用。腺苷蛋氨酸和细胞黄素产生的保护作用最大，二氢槲皮素的作用不明显。在用腺苷蛋氨酸治疗的大鼠中，AST 活性在第 7 天即下降，并保持在该水平直到实验结束；ALT、碱性磷酸酶和 γ-谷氨酰转移酶活性在研究的第 21 天和第 28 天下降。细胞黄素产生了类似的作用，在第 21 天和第 28 天观察到二氢槲皮素对 AST、ALT、碱性磷酸酶的作用以及在第 28 天对 γ-谷氨酰转移酶的作用。这些结果证实了在癫痫患者长期使用抗惊厥药治疗的情况下使用保肝药。