We examined the effects of 72-h exposure to atorvastatin and rosuvastatin in concentrations of 2-10 nM on the cytokine expression in LPS/IFNγ-activated monocyte/macrophages derived from peripheral blood monocytes of healthy donors by culturing in the presence of GM-CSF. Pretreatment with statins was found to inhibit cytokine production in monocytes/macrophages after activation, while the level of cytokine mRNA in cells did not decrease. The number of cells containing active caspase-3 decreased in the culture. Culturing of monocytes/macrophages with statins was accompanied by changes in cell morphology and deceleration of cell growth. Cellular effects of "lipophilic" atorvastastin were observed at lower concentration compared to "hydrophilic" rosuvastatin.

中文翻译：

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3-羟基-3-甲基戊二酰辅酶 a 还原酶 (他汀类药物) 的抑制剂在人单核细胞/巨噬细胞培养中抑制分化并减少 LPS/IFNγ 诱导的细胞因子产生

我们通过在 GM-CSF 存在下培养，研究了 72 小时暴露于浓度为 2-10 nM 的阿托伐他汀和瑞舒伐他汀对来自健康供体外周血单核细胞的 LPS/IFNγ 激活的单核细胞/巨噬细胞中细胞因子表达的影响. 发现用他汀类药物预处理可抑制活化后单核细胞/巨噬细胞中细胞因子的产生，而细胞中细胞因子 mRNA 的水平并未降低。培养物中含有活性 caspase-3 的细胞数量减少。用他汀类药物培养单核细胞/巨噬细胞伴随着细胞形态的变化和细胞生长的减速。与“亲水性”瑞舒伐他汀相比，在较低浓度下观察到“亲脂性”阿托伐他汀的细胞作用。