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Regulation of Vascular Smooth Muscle Contractions in the Model of Metabolic Syndrome
Bulletin of Experimental Biology and Medicine ( IF 0.7 ) Pub Date : 2020-12-01 , DOI: 10.1007/s10517-020-05031-0
Yu G Birulina 1 , V V Ivanov 1 , E E Buyko 1 , E P Efremkina 1 , L V Smagliy 1 , I V Kovalev 1 , A V Nosarev 1 , S V Gusakova 1
Affiliation  

Reduced glucose tolerance, hyperglycemia, and imbalance in lipid levels were found in rats with metabolic syndrome induced by a high-fat, high-carbohydrate diet. The contractile responses of intact and endothelium-denuded aortic smooth muscle segments from rats with metabolic syndrome to application of acetylcholine, phenylephrine, sodium nitroprusside, and forskolin were studied by mechanographic method. It was found that endothelial dysfunction develops against the background of metabolic and hemodynamic disorders in metabolic syndrome. It was shown that the regulation of vasoconstrictor reactions of vascular smooth muscles in metabolic syndrome is due to a decrease in Ca2+ entry, mainly voltage-independent, as well as changes in the function of cGMP- and cAMP-activated K+-channels.

中文翻译:

代谢综合征模型中血管平滑肌收缩的调节

在高脂肪、高碳水化合物饮食诱导的代谢综合征大鼠中发现葡萄糖耐量降低、高血糖和脂质水平失衡。用机械图方法研究了代谢综合征大鼠完整的和内皮剥脱的主动脉平滑肌节段对乙酰胆碱、去氧肾上腺素、硝普钠和毛喉素的收缩反应。发现内皮功能障碍是在代谢综合征中代谢和血流动力学紊乱的背景下发展的。结果表明,代谢综合征中血管平滑肌的血管收缩反应的调节是由于 Ca2+ 进入的减少,主要与电压无关,以及 cGMP-和 cAMP-激活的 K+-通道功能的变化。
更新日期:2020-12-01
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