Starch aerogels are attractive materials for biomedical applications because of their low density and high open porosity coupled with high surface areas. However, the lack of macropores in conventionally manufactured polysaccharide aerogels is a limitation to their use as scaffolds for regenerative medicine. Moreover, the stability under storage of polysaccharide aerogels is critical for biomedical purposes and scarcely studied so far. In this work, the induction of a new macropore population (1–2 μm) well integrated into the starch aerogel backbone was successfully achieved by the incorporation of zein as a porogen. The obtained dual-porous aerogels were evaluated in terms of composition as well as morphological, textural, and mechanical properties. Stability of aerogels upon storage mimicking the zone II (25 °C, 65% relative humidity) according to the International Council for Harmonization guideline of climatic conditions was checked after 1 and 3 months from morphological, physicochemical, and mechanical perspectives. Zein incorporation induced remarkable changes in the mechanical performance of the end aerogel products and showed a preventive effect on the morphological changes during the storage period.

中文翻译：

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用于生物医学的淀粉气凝胶制剂的稳定性研究

淀粉气凝胶由于其低密度和高开孔率以及高表面积而成为生物医学应用中有吸引力的材料。然而，常规制造的多糖气凝胶中缺乏大孔，限制了它们用作再生医学的支架。此外，多糖气凝胶在储存下的稳定性对于生物医学目的是至关重要的，到目前为止还很少进行研究。在这项工作中，通过掺入玉米醇溶蛋白作为致孔剂，成功地诱导了一个很好地整合到淀粉气凝胶骨架中的新大孔（1-2μm）。对获得的双孔气凝胶进行了组成以及形态，质地和机械性能方面的评估。模仿II区（25°C，在1个月和3个月后，从形态，物理化学和机械角度出发，根据国际协调委员会气候条件指南检查了相对湿度为65％）。玉米醇溶蛋白的掺入导致最终气凝胶产品的机械性能发生显着变化，并在储存期间对形态变化表现出预防作用。