R⁵, R⁶, and R⁷ are each independently H, halo, C1–C6 alkyl, C1–C6 haloalkyl, C1–C6 alkoxy, or C1–C6 haloalkoxy; and R⁸ is C1–C6 alkyl; R⁵ is W-(CH₂)_n-R^z, C1–C6 alkylsulfanyl, -O-(CH₂)_p-R^w, or -O-(CH₂)^p-N(C1–C6alkyl)₂; R⁶ and R⁷ are each independently H, halo, C1–C6 alkyl, C1–C6 haloalkyl, C1–C6 alkoxy, or C1–C6 haloalkoxy; and R⁸ is H; R⁵ and R⁶ are each independently H, halo, C1–C6 alkyl, C1–C6 haloalkyl, C1–C6 alkoxy, or C1–C6 haloalkoxy; R⁷ is W-(CH₂)_n-R^z, -C = C-R^x, or 3–6 membered cycloalkyl or phenyl, wherein said 3–6 membered cycloalkyl or phenyl is substituted with 1–3 substituents selected from a group consisting of C1–C6 alkoxy, CN, and -C(O)NH₂; and R⁸ is H; or R⁵ is H, halo, C1–C6 alkyl, C1–C6 haloalkyl, C1–C6 alkoxy, or C1–C6 haloalkoxy; R⁶ and R⁷, together with the carbon atoms to which they are attached, form a ring of formula ; and R⁸ is H; Hameed, S. Na_v 1.7 and Na_v 1.8: Role in the pathophysiology of pain. Molecular Pain 2019, 15, 10.1177/2F1744806919858801 Han, C.; Huang, J.; Waxman, S. G. Sodium channel Na_v 1.8: Emerging links to human disease. Neurology 2016, 86 (5), 473–483. Gilchrist, J.; Bosmans, F. Using voltage-sensor toxins and their molecular targets to investigate Na_v1.8 gating. J. Physiol. 2018, 596 (10), 1863–1872. The author declares no competing financial interest. The author declares no competing financial interest. This article has not yet been cited by other publications.

中文翻译：

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羧酰胺作为钠通道的调节剂

R ⁵、R ⁶和R ⁷各自独立地为H、卤素、C1-C6烷基、C1-C6卤代烷基、C1-C6烷氧基或C1-C6卤代烷氧基；R ⁸为C1-C6烷基；R ⁵是W-(CH ₂ ) _n -R ^z、C1-C6烷基硫烷基、-O-(CH ₂ ) _p -R ^w或-O-(CH ₂ ) ^p -N(C1-C6烷基) ₂；R ⁶和R ⁷各自独立地为H、卤素、C1-C6烷基、C1-C6卤代烷基、C1-C6烷氧基或C1-C6卤代烷氧基；R ⁸是H；R ⁵和 R ⁶各自独立地为 H、卤素、C1-C6 烷基、C1-C6 卤代烷基、C1-C6 烷氧基或 C1-C6 卤代烷氧基；R ⁷为W-(CH ₂ ) _n -R ^z，-C=CR ^x，或3-6元环烷基或苯基，其中所述3-6元环烷基或苯基被1-3个选自下组的取代基取代C1-C6烷氧基、CN和-C(O)NH ₂；R ⁸是H；或R ⁵是H、卤素、C1-C6烷基、C1-C6卤代烷基、C1-C6烷氧基或C1-C6卤代烷氧基；R ⁶和R ⁷与它们所连接的碳原子一起形成下式的环；R ⁸是H；哈米德，S.Na _v 1.7 和 Na _v 1.8：在疼痛病理生理学中的作用。分子痛 2019 , 15 , 10.1177/2F1744806919858801韩，C。黄，J。瓦克斯曼，SG钠通道 Na _v 1.8：与人类疾病的新联系。神经病学 2016 年，86（5），473-483。吉尔克里斯特，J。博斯曼斯，F.使用电压传感器毒素及其分子靶标研究 Na _v 1.8 门控。J.生理学。 2018 , 596 (10), 1863–1872。作者声明没有竞争性经济利益。作者声明没有竞争性经济利益。这篇文章还没有被其他出版物引用。