At present, secondary immune deficiencies have become a clinical problem, recognized in different specialties. The aim of this paper was to increase awareness and support the need for screening at-risk populations. Secondary immune deficiencies result in variety of conditions, but not all of them require immunoglobulin replacement therapy, as specific antibody response might be preserved. Moreover, the management of secondary immune deficiencies vary between countries and different medical disciplines. This literature review presents the most common causes and clinical presentation of secondary immunodeficiencies with predominant impaired antibody production. We present diagnostic guidelines for patients at-risk, with an emphasis on the role of prophylactic vaccination as a treatment and diagnostic tool. This review considers the specificity and disparities of the Polish healthcare system and ultimately, suggests that management teams should include a clinical immunologist experienced in the treatment of humoral immunodeficiencies.

中文翻译：

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具有主要抗体缺陷的继发性免疫缺陷：波兰专家的多学科观点

目前，继发性免疫缺陷已成为临床问题，已在不同专业领域得到认可。本文的目的是提高认识并支持筛查高危人群的需求。继发性免疫缺陷会导致多种疾病，但并非所有人都需要免疫球蛋白替代疗法，因为可能会保留特异性抗体反应。此外，各国和不同医学学科对继发性免疫缺陷的管理也有所不同。这篇文献综述介绍了主要的抗体产生受损的继发性免疫缺陷的最常见原因和临床表现。我们为有风险的患者提供了诊断指南，重点是预防性疫苗作为治疗和诊断工具的作用。