ABSTRACT

We investigated the gene-expression variation among humans by analysing previously published mRNA-seq and ribosome footprint profiling of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation values and found that the top 5% most variable genes had special features compared to the rest of the genome, such as lower mRNA levels and shorter half-lives coupled to increased translation efficiency. We observed that these genes are mostly involved with immune response and have a pleiotropic effect on disease phenotypes, indicating that asymptomatic conditions contribute to the gene expression diversity of healthy individuals.

摘要

我们通过分析先前发表的来自健康供体的心脏左心室的 mRNA-seq 和核糖体足迹分析，研究了人类之间的基因表达变异。我们根据基因的变异系数对基因进行排序，发现前 5% 的变异基因与基因组的其他部分相比具有特殊的特征，例如较低的 mRNA 水平和较短的半衰期，以及翻译效率的提高。我们观察到这些基因主要与免疫反应有关，并且对疾病表型具有多效性，这表明无症状条件有助于健康个体的基因表达多样性。