The propargylamine motif is not only prevalent in a wide variety of pharmaceuticals and other biologically active compounds but also utilized as a versatile building block in organic synthesis. Among the various methods for the synthesis of propargylamine derivatives, A³‐coupling represents one of the most general and attractive routes, since it offers the possibility for the construction of complex molecules from simple starting materials (amines, aldehydes, and alkynes) in one‐step with high atom economy. However, the use of volatile alkynes is the main disadvantage of this reaction. Recently, alkynyl carboxylic acids were successfully used as easily accessible and high stable surrogates for alkynes (via in situ decarboxylation) in A³‐coupling reactions. This Focus‐Review aims to give an overview of the decarboxylative A³‐coupling reactions by hoping that it will be beneficial to elicit further research in this appealing research arena. A special emphasis is placed on mechanistic aspect of reactions which may allow possible new insights into catalyst improvement.

中文翻译：

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脱羧A3偶联反应：概述

炔丙胺基序不仅在多种药物和其他生物活性化合物中普遍存在，而且还用作有机合成中的通用构件。在各种炔丙基胺衍生物的合成方法中，A ³偶联是最通用和最有吸引力的途径之一，因为它为从简单的原料（胺，醛和炔烃）中合成复杂分子提供了可能性。高度经济的步骤。但是，使用挥发性炔烃是该反应的主要缺点。最近，炔基羧酸已成功地用作A ^3中炔烃的易获得且高度稳定的替代物（通过原位脱羧）偶联反应。本“重点综述”旨在概述脱羧A ³偶联反应，以期希望在这个有吸引力的研究领域中引发进一步的研究是有益的。特别强调反应的机械方面，这可能使人们对催化剂的改进有新的认识。