1 INTRODUCTION

Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a primary intestinal T-cell lymphoma proposed as a new disease entity in the revised fourth World Health Organization classification. Recent reports showed that MEITL is characterized by a poor prognosis and a high frequency of local relapse and extra-intestinal involvement, including the central nervous system (CNS) (Kubota & Kusaba, 2018; Yi et al., 2019); however, data from flow cytometric analysis of MEITL are scarce. A case of chemorefractory MEITL with CNS relapse is presented. The patient received an autologous transplant followed by an allogeneic transplant. During the clinical course, imaging modalities including positron emission tomography-computed tomography (PET-CT) were not useful for assessing treatment response, because the mass lesions disappeared after chemotherapy and transplantation; however, the therapeutic effect was evaluated by detecting residual lymphoma cells using flow cytometry (FCM).

中文翻译：

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通过流式细胞术监测肿瘤细胞可以快速评估单形性上皮性肠 T 细胞淋巴瘤的疾病进展

1 简介

单形性上皮性肠 T 细胞淋巴瘤 (MEITL) 是一种原发性肠 T 细胞淋巴瘤，在修订的第四版世界卫生组织分类中被提议作为一种新的疾病实体。最近的报告显示，MEITL 的特点是预后不良，局部复发和肠外受累频率高，包括中枢神经系统 (CNS) (Kubota & Kusaba,  2018 ; Yi et al.,  2019); 然而，来自 MEITL 流式细胞仪分析的数据很少。介绍了一例伴有 CNS 复发的化学难治性 MEITL。患者接受了自体移植，然后进行了同种异体移植。在临床过程中，包括正电子发射断层扫描-计算机断层扫描（PET-CT）在内的成像方式对评估治疗反应没有用处，因为肿块病变在化疗和移植后消失了；然而，治疗效果是通过使用流式细胞仪 (FCM) 检测残留的淋巴瘤细胞来评估的。