Abstract Organophosphates cause increased oxidative susceptibility of erythrocytes and changes in erythrocyte deformability ability. We aim is to investigate the role of ethion (ETH) on erythrocyte deformability and to show whether vinpocetine (VIN) and carnosine (CAR) are protective against these changes. The study was performed on Sprague Dawley rats with an average weight of 220 ± 40 g and 4–5 months old. Six experimental groups were composed of 10 rats per group. Hematological parameters, erythrocyte deformability, % hemolysis, 2.3bisphosphoglycerate, and methemoglobin values were measured in blood samples taken after 10 days of drug application. Erythrocyte count, hemoglobin amount, hematocrit value, serum potassium level, and erythrocyte deformability decreased in the ETH group. Leukocyte, platelet count, methemoglobin amount, and % hemolysis rates increased in the ETH group. The values of the ETH + CAR and ETH + VIN groups were found to be closer to the control group. In organophosphate poisoning such as ETH, the deformability ability of erythrocytes exposed to constant oxidative stress is changing, and therefore their ability to deliver oxygen to tissues is negatively affected. VIN and CAR may have improve on erythrocyte deformability in this type of intoxication.

中文翻译：

---

乙硫磷对红细胞变形能力的影响

摘要 有机磷导致红细胞氧化敏感性增加和红细胞变形能力改变。我们的目标是研究乙硫磷 (ETH) 对红细胞变形能力的作用，并证明长春西汀 (VIN) 和肌肽 (CAR) 是否对这些变化有保护作用。该研究是对平均体重为 220 ± 40 克、4-5 个月大的 Sprague Dawley 大鼠进行的。六个实验组由每组10只大鼠组成。在施用药物 10 天后采集的血液样本中测量血液学参数、红细胞变形能力、溶血百分比、2.3 二磷酸甘油酸酯和高铁血红蛋白值。ETH 组的红细胞计数、血红蛋白量、血细胞比容值、血清钾水平和红细胞变形能力降低。白细胞、血小板计数、高铁血红蛋白量、ETH 组溶血率增加。发现ETH + CAR和ETH + VIN组的值更接近对照组。在 ETH 等有机磷中毒中，暴露于持续氧化应激的红细胞的变形能力正在发生变化，因此它们向组织输送氧气的能力受到负面影响。VIN 和 CAR 可能在这种类型的中毒中改善红细胞变形能力。