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Palladium in biological media: Can the synthetic chemist's most versatile transition metal become a powerful biological tool?
Journal of Inorganic Biochemistry ( IF 3.9 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.jinorgbio.2020.111317
Richard C Brewster 1 , Eva Klemencic 1 , Amanda G Jarvis 1
Affiliation  

Palladium catalysed reactions are ubiquitous in synthetic organic chemistry in both organic solvents and aqueous buffers. The broad reactivity of palladium catalysis has drawn interest as a means to conduct orthogonal transformations in biological settings. Successful examples have been shown for protein modification, in vivo drug decaging and as palladium-protein biohybrid catalysts for selective catalysis. Biological media represents a challenging environment for palladium chemistry due to the presence of a multitude of chelators, catalyst poisons and a requirement for milder reaction conditions e.g. lower temperatures. This review looks to identify successful examples of palladium-catalysed reactions in the presence of proteins or cells and analyse solutions to help to overcome the challenges of working in biological systems.



中文翻译:

生物介质中的钯:合成化学家最通用的过渡金属能否成为强大的生物工具?

钯催化的反应在有机溶剂和水性缓冲液中的合成有机化学中无处不在。钯催化的广泛反应性作为在生物环境中进行正交转化的一种手段引起了人们的兴趣。成功的例子已被证明用于蛋白质修饰、体内药物降解和作为选择性催化的钯-蛋白质生物杂化催化剂。由于存在大量螯合剂、催化剂毒物以及对温和反应条件的要求,生物介质对钯化学来说是一个具有挑战性的环境,例如较低的温度。本综述旨在确定在蛋白质或细胞存在下钯催化反应的成功例子,并分析解决方案以帮助克服在生物系统中工作的挑战。

更新日期:2020-12-10
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