α-Amylase inhibitors (α-AIs) delay digestion of dietary starch by inhibiting α-amylase in the gut, thereby reducing the postprandial glycemia, which is beneficial to the patients with obesity and diabetes. The proteinaceous α-AIs from wheat can effectively control starch digestion and regulate postprandial hyperglycemia. However, their gastric intolerance remains a challenge, which limits its commercial production and industrial application. In this study, sodium alginate/chitosan aerogels loaded with wheat protein α-AIs were prepared and evaluated as potential transportation and protection matrices for important components in food or pharmaceutical applications. Specifically, the biodegradable aerogel cross-linked with sodium alginate-chitosan-calcium chloride, has a large surface area and open porous structure, which can adsorb staple wheat proteins as an integrated edible material to block around 88,660 U/g of α-amylase activity. The aerogel particles were able to protect the activity of wheat α-AIs in the stomach, leading to the slow passage of the wheat α-AIs through the small intestine to inhibit starch digestion more effectively. Animal experiments further showed that the postprandial blood glucose levels in rats were effectively controlled through delayed increase, after administration of wheat protein-functionalized aerogel particles loaded with wheat α-AIs, which are natural biological macromolecules. This is a novel, safe, and economical method for the prevention and pretreatment of diabetes.

α-淀粉酶抑制剂（α-AIs）通过抑制肠道中的α-淀粉酶来延迟膳食淀粉的消化，从而降低餐后血糖，这对肥胖和糖尿病患者有益。小麦中的蛋白质α-AI可以有效控制淀粉的消化并调节餐后高血糖。然而，它们的胃不耐受性仍然是一个挑战，这限制了其商业生产和工业应用。在这项研究中，制备了载有小麦蛋白α-AI的海藻酸钠/壳聚糖气凝胶，并将其评估为食品或药物应用中重要成分的潜在运输和保护基质。具体而言，与藻酸钠-壳聚糖-氯化钙交联的可生物降解气凝胶，具有较大的表面积和开放的多孔结构，它可以吸收小麦的主要蛋白质作为一种可食的综合材料，从而阻断约88,660 U / g的α-淀粉酶活性。气凝胶颗粒能够保护胃中小麦α-AIs的活性，从而导致小麦α-AIs缓慢通过小肠，从而更有效地抑制淀粉的消化。动物实验进一步表明，在施用载有天然生物大分子小麦α-AIs的小麦蛋白官能化气凝胶颗粒后，可通过延迟增加来有效控制大鼠餐后血糖水平。这是一种预防和预处理糖尿病的新颖，安全，经济的方法。气凝胶颗粒能够保护胃中小麦α-AIs的活性，从而导致小麦α-AIs缓慢通过小肠，从而更有效地抑制淀粉的消化。动物实验进一步表明，在施用载有天然生物大分子小麦α-AIs的小麦蛋白官能化气凝胶颗粒后，可通过延迟增加来有效控制大鼠餐后血糖水平。这是一种预防和预处理糖尿病的新颖，安全，经济的方法。气凝胶颗粒能够保护胃中小麦α-AIs的活性，从而导致小麦α-AIs缓慢通过小肠，从而更有效地抑制淀粉的消化。动物实验进一步表明，在施用载有天然生物大分子小麦α-AIs的小麦蛋白官能化气凝胶颗粒后，可通过延迟增加来有效控制大鼠餐后血糖水平。这是一种预防和预处理糖尿病的新颖，安全，经济的方法。施用含有天然生物大分子小麦α-AIs的小麦蛋白功能化气凝胶颗粒后。这是一种预防和预处理糖尿病的新颖，安全，经济的方法。施用含有天然生物大分子小麦α-AIs的小麦蛋白功能化气凝胶颗粒后。这是一种预防和预处理糖尿病的新颖，安全，经济的方法。