Aerobic granular sludge (AGS) technology has been recognized as a promising alternative to alleviate the osmotic stress of hypersaline wastewater. However, the response of AGS process to composite hypersaline wastewater on removal performance and populations was yet to be understood. In this work, two sequenced batch reactors were operated in parallel in absence (R0) and presence (R1) of high concentration sulfate as proxy for single and mixed salts (30 g salt·L^-1) respectively. Results demonstrated that the presence of sulfate in hypersaline wastewater enhanced chemical oxygen demand (COD) and total nitrogen (TN) removals of 95.3 % and 65.5 % respectively with lower accumulations of nitrite. High-throughput 16S rRNA gene sequencing technique elucidated that Denitromonas (31.6 %) and Xanthomarina (17.0 %) were the more dominant genera in AGS response to mixed salts with high sulfate and laid the biological basis for strengthening removal performance. The enrichment of halophilic Luteococcus (23.5 %) in the AGS surface indicated the potential role of mixed salts in shaping the physical properties and surface population structure of AGS. Our work could facilitate the potential applications of AGS technology for industrial hypersaline wastewater treatment with complicated compositions.

好氧颗粒污泥（AGS）技术已被认为是减轻高盐废水渗透压的一种有前途的替代方法。然而，AGS工艺对复合高盐废水对去除性能和种群的响应尚待了解。在这项工作中，两个顺序分批反应器在高浓度硫酸盐不存在（R0）和存在（R1）的情况下并行运行，分别代替单一盐和混合盐（30 g盐·L ^-1）。结果表明，高盐度废水中硫酸盐的存在分别增加了95.3％和65.5％的化学需氧量（COD）和总氮（TN）去除量，同时亚硝酸盐的积累量较低。高通量16S rRNA基因测序技术阐明了Denitromonas（31.6％）和黄嘌呤（17.0％）是AGS对高硫酸盐混合盐反应的更主要属，为增强去除性能奠定了生物学基础。AGS表面中嗜盐性黄球菌的含量（23.5％）表明混合盐在塑造AGS的物理性质和表面种群结构中的潜在作用。我们的工作可以促进AGS技术在具有复杂成分的工业高盐废水处理中的潜在应用。