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Microwave-assisted synthesis of superparamagnetic mesoporous hydroxyapatite nanorods for various biomedical applications
Ceramics International ( IF 5.2 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.ceramint.2020.11.234
Gopalu Karunakaran , Eun-Bum Cho , Govindan Suresh Kumar , Evgeny Kolesnikov , Arkhipov Dmitry , Saheb Ali

Abstract Advanced methods to design biocompatible mesoporous superparamagnetic nanoparticles are required for various healthcare applications. This work was designated to synthesize superparamagnetic mesoporous hydroxyapatite (HAp) nanorods (NRs) with the intrinsic pure phase through the doping of cobalt ions inside it. This nanoparticle was synthesized using a black Scallop seashell as the low cost calcium sources using oxalic acid as a strong chelating agent via microwave synthesis. The prepared magnetic HAp NRs are analyzed by diverse methods to understand the clarity of phase and its nanostructural features. XRD and EDX results prove that Co is distributed well in the HAp nanoparticles without affecting its structure. The BET surface areas of CoHAp-1, CoHAp-2, and pristine HAp NRs were found to be 69, 126, and 97 m2 g−1, correspondingly. Further, evaluated pore volume of CoHAp-1, CoHAp-2, and pristine HAp NRs are identified to be 0.0275, 0.0349, and 0.0368 cm3 g−1 and also pore diameters were found as 3.02, 4.67, and 4.71 nm. Hence, the HAp mesoporous NRs with higher surface area were achieved with the incorporation of Co in the HAp system. The superparamagnetic characteristics were identified only in the Co-doped HAp samples. The high saturation magnetization of 0.20 Am2 kg-1 was observed with the high doping of Co ions. Toxicity of the pristine and the Co-incorporated HAp samples were evaluated using zebrafish. The toxicity result reveals that Co incorporations in HAp do not affect significantly the biocompatible nature compared to the pristine HAp sample. Antibacterial test shows excellent antibacterial activities for Co-HAp samples among different pathogens. Hence, the approach of oxalic acid-associated microwave mediated synthesis of intrinsic mesoporous superparamagnetic HAp NRs from naturally occurring seashells as a precursor can be a superior method for obtaining nanomaterials towards various applications like magnetic resonance imaging, targeting of drug, hyperthermia, and cancer treatments.

中文翻译:

用于各种生物医学应用的超顺磁性介孔羟基磷灰石纳米棒的微波辅助合成

摘要 各种医疗保健应用需要先进的方法来设计生物相容性介孔超顺磁性纳米粒子。这项工作旨在通过在其中掺杂钴离子来合成具有本征纯相的超顺磁性介孔羟基磷灰石 (HAp) 纳米棒 (NRs)。这种纳米颗粒是使用黑色扇贝贝壳作为低成本钙源,使用草酸作为强螯合剂通过微波合成合成的。通过多种方法分析制备的磁性 HAp NR,以了解相的清晰度及其纳米结构特征。XRD 和 EDX 结果证明 Co 在 HAp 纳米粒子中分布良好而不影响其结构。发现 CoHAp-1、CoHAp-2 和原始 HAp NRs 的 BET 表面积分别为 69、126 和 97 m2 g-1。此外,CoHAp-1、CoHAp-2 和原始 HAp NR 的评估孔体积被确定为 0.0275、0.0349 和 0.0368 cm3 g-1,并且孔径被发现为 3.02、4.67 和 4.71 nm。因此,通过在 HAp 体系中掺入 Co 实现了具有更高表面积的 HAp 介孔 NR。仅在 Co 掺杂的 HAp 样品中发现了超顺磁特性。在 Co 离子的高掺杂下观察到 0.20 Am2 kg-1 的高饱和磁化强度。使用斑马鱼评估原始和共同掺入的 HAp 样品的毒性。毒性结果表明,与原始 HAp 样品相比,HAp 中的 Co 掺入不会显着影响生物相容性。抗菌试验表明,Co-HAp 样品对不同病原体具有优异的抗菌活性。因此,
更新日期:2020-12-01
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