Nitric oxide (NO) is an important biological messenger involved in the treatment of bacterial infections, but its controlled and targeted release in bacterial infections remains a major challenge. Herein, an intelligent NO nanogenerator triggered by near-infrared (NIR) light is constructed for targeted treatment of P. aeruginosa bacterial infection. Since maleimide can recognize and attach to the pilus of T4P of P. aeruginosa, we adopt this strategy to achieve the accurate release of therapeutic drugs at the infection site, i.e., after maleimide targets Gram-negative bacteria, the SNP@MOF@Au-Mal nanogenerator will release NO and generate ROS in situ from the inorganic photosensitizer gold nanoparticles under NIR irradiation to achieve synergistic antibacterial effect. In vivo experiments proved that the bacterial burden on the wound was reduced by 97.7%. Additionally, the nanogenerator was shown to promote the secretion of growth factors, which play a key role in regulating inflammation and inducing angiogenesis. This strategy has the advantage of generating a high concentration of NO in situ to promote the transfer of more NO and its derivatives (N₂O₃, ONOO⁻) to bacteria, thereby significantly improving the antibacterial effect. The multifunctional antibacterial platform has been demonstrated as a good carrier for gas therapy because of its simple and efficient gas release performance, indicating its great potential for the treatment of drug-resistant bacterial infections.

一氧化氮（NO）是参与细菌感染治疗的重要生物信使，但其在细菌感染中的受控释放和靶向释放仍然是一项重大挑战。本文中，构建了由近红外（NIR）光触发的智能NO纳米发生器，用于铜绿假单胞菌细菌感染的靶向治疗。由于马来酰亚胺可以识别并附着到铜绿假单胞菌的T4P菌毛上，因此我们采用这种策略来实现治疗药物在感染部位的准确释放，即在马来酰亚胺靶向革兰氏阴性细菌后，SNP @ MOF @ Au- Mal纳米发生器将释放NO并原位产生ROS无机光敏剂金纳米颗粒在近红外照射下获得协同抗菌作用。体内实验证明伤口上的细菌负担减少了97.7％。此外，纳米发生器被证明可以促进生长因子的分泌，而生长因子在调节炎症和诱导血管生成中起关键作用。这一策略具有产生NO的浓度高的优点在原位，以促进更NO和其衍生物（N的转移₂ Ó ₃，ONOO ^-）对细菌，从而显着提高抗菌效果。多功能抗菌平台因其简单有效的气体释放性能而被证明是气体疗法的良好载体，表明其在治疗耐药细菌感染方面具有巨大潜力。