Abstract

An urgent task of modern medicine is the search for drugs that can stop or slow down the course of neurodegenerative diseases, in particular Alzheimer’s disease. The aim of this work was to determine the effect of fullerenol C₆₀(OH)₃₀ on the pathogenesis of Alzheimer’s disease in the Drosophila melanogaster model. The effect of fullerenol on the life expectancy, the level of geotaxis, learning and memory, and the levels of neurodegeneration and reactive oxygen species in the animal brain was studied. Based on the results, it can be assumed that fullerenol C₆₀(OH)₃₀ is a promising agent for the development of complex therapy for Alzheimer’s disease.

中文翻译：

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用阿尔茨海默氏病模型研究富勒烯醇C 60（OH）30的神经保护特性

摘要

现代医学的紧迫任务是寻找可以停止或减慢神经退行性疾病，特别是阿尔茨海默氏病进程的药物。这项工作的目的是确定果蝇C ₆₀（OH）₃₀在果蝇模型中阿尔茨海默氏病发病机理中的作用。研究了富勒烯醇对动物脑的预期寿命，趋性，学习和记忆水平以及神经变性和活性氧水平的影响。根据结果​​，可以假设富勒烯醇C ₆₀（OH）₃₀是开发阿尔茨海默氏病综合疗法的有前途的药物。