Due to the high toxicity of lead ions (Pb²⁺) and volatile organic compounds (VOCs) to human health and the environment, increasing attention has been paid by scientists to the development of simple, flexible and sensitive sensors or methods that are capable of tracing Pb²⁺ ions or VOCs with colorimetric visualization. In this study, the fabrication of colorimetric sensors based on histidine-functionalized diacetylene (His-DA), chromatic π-conjugated liposomes, for tracing Pb²⁺ ions was described. With a suitable molar ratio (4:1) between the10,12-pentacosadiynoic acid (PCDA) and His-DA monomers, the histidine units of the hybrid liposomes could rationally interrupt the efficient backbone length of polydiacetylene (PDA) chains, which causes the probe to be highly sensitive and selective for colorimetric visualization of tracing Pb²⁺ ions. Moreover, the His-PDA films also displayed sensitivity to volatile organic solvents or vapors, which could promote vivid color changes from blue to purple or pink. These interesting findings indicate that histidine-functionalized diacetylene may offer a promising way to design smart devices for real applications of sensing or tracing hazardous substances in the future.

由于铅离子（Pb ²⁺）和挥发性有机化合物（VOC）对人类健康和环境具有高毒性，因此科学家日益关注开发具有以下功能的简单，灵活和灵敏的传感器或方法：比色可视化示踪Pb ²⁺离子或VOC。在这项研究中，基于组氨酸官能化的二乙炔（His-DA）和有色π共轭脂质体的比色传感器的制造，用于痕量Pb ²⁺描述了离子。在10,12-戊二碳二烯酸（PCDA）和His-DA单体之间具有合适的摩尔比（4：1）时，杂化脂质体的组氨酸单元可以合理地中断聚二乙炔（PDA）链的有效骨架长度，从而导致探针对于痕量Pb ²⁺离子的比色可视化具有很高的灵敏度和选择性。此外，His-PDA膜还显示出对挥发性有机溶剂或蒸气的敏感性，这可以促进从蓝色到紫色或粉红色的生动颜色变化。这些有趣的发现表明，组氨酸官能化的二乙炔可能会提供一种有前途的方法来设计智能设备，以便将来在实际应用中检测或追踪有害物质。