Abstract A facile, efficient, precise and reliable method based on liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was established to separate and determine two typical quinolone antibiotics (ofloxacin and lomefloxacin) and two typical sulfonamide antibiotics (sulfadimeisoxazole and sulfadimidine). The photocatalytic degradation effects, identification of intermediate products and decomposition pathways of these four antibiotics degraded by Bi2MoO6/Bi2WO6/MWCNTs composite catalyst were analyzed using the developed HPLC-MS/MS method. It was found that all four antibiotics can be synchronously decomposed with the ultrahigh removal rates of above 95%. Three main degradation reactions of quinolones were detected: the decarboxylation of quinolones, the ring opening reaction of piperazine and the defluorination of C-F. The main decomposition reactions of sulfonamides included the sulfonamide bond (S-N) breaking at the active sites, the oxidation of the amino acids on the benzene rings, and the substitution and oxidation ring opening reaction of pyrimidine. This study not only developed a detailed isolation and identification method for the degradation pathways and mechanisms of mixed pharmaceutical pollutants, but also provides a superb photocatalyst for the removal of multiplex pharmaceutical pollutants.

中文翻译：

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在 Bi2MoO6/Bi2WO6/MWCNTs 光催化剂的帮助下深入了解喹诺酮类和磺胺类药物的降解、中间产物鉴定和分解途径

摘要 建立了一种基于液相色谱-串联质谱 (HPLC-MS/MS) 的简便、高效、精确、可靠的方法来分离和测定两种典型的喹诺酮类抗生素（氧氟沙星和洛美沙星）和两种典型的磺胺类抗生素（磺胺二异恶唑和磺胺二甲嘧啶）。 . 使用开发的 HPLC-MS/MS 方法分析了 Bi2MoO6/Bi2WO6/MWCNTs 复合催化剂降解的这四种抗生素的光催化降解效果、中间产物的鉴定和分解途径。发现四种抗生素均能同步分解，去除率高达95%以上。检测到喹诺酮类的三个主要降解反应：喹诺酮类的脱羧、哌嗪的开环反应和CF的脱氟。磺胺类的主要分解反应包括活性位点的磺酰胺键（SN）断裂、苯环上氨基酸的氧化以及嘧啶的取代和氧化开环反应。该研究不仅为混合药物污染物的降解途径和机制发展了详细的分离和鉴定方法，而且为去除多重药物污染物提供了极好的光催化剂。