Background

Interaction between metals is known from earlier studies, in which one metal influences the absorption and functional role of other. Lead is known to cause debilitating effects in living organisms and also prevents several essential trace metals from functioning normally.

Methods

The relevant literature using the key words lead toxicity, lead zinc interaction, zinc nutrition and the ability of zinc to act against lead has been reviewed.

Results

Role of several nutrients in reducing the manifestations of toxic metals have been elucidated recently. Lead damages bio-membranes, causes cognitive disabilities and disturbs the normal process of DNA replication and transcription. Zinc on the other hand helps in proper maintenance of the cellular membranes and plays an important role as a metal cofactor in most of the proteins vital for membrane integrity. Zinc has essential role in cognitive functioning, zinc finger proteins and significantly neutralizes most toxic effects of lead.

Conclusion

Increased lead exposure and limited resources for tackling lead poisoning may cause an increased possibility of future environmental emergencies. Interactions between essential nutrient metals and non-essential toxic metals may act as important factor which can be used to target the metal toxicities. An assumption is made that the lead toxicity can be reduced by maintaining the status of essential trace metals like zinc.

中文翻译：

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铅和锌的相互作用——锌对铅相关毒性表现的影响

背景

金属之间的相互作用从早期的研究中得知，其中一种金属会影响另一种金属的吸收和功能作用。众所周知，铅会导致生物体衰弱，还会阻止几种必需的微量金属正常发挥作用。

方法

使用关键词铅毒性、铅锌相互作用、锌营养和锌对铅的作用能力的相关文献进行了综述。

结果

最近已经阐明了几种营养素在减少有毒金属表现方面的作用。铅会破坏生物膜，导致认知障碍并扰乱 DNA 复制和转录的正常过程。另一方面，锌有助于细胞膜的适当维护，并在大多数对膜完整性至关重要的蛋白质中作为金属辅助因子发挥重要作用。锌在认知功能、锌指蛋白和显着中和铅的大多数毒性作用中具有重要作用。

结论

铅暴露增加和用于解决铅中毒的资源有限可能会增加未来发生环境紧急情况的可能性。必需营养金属和非必需有毒金属之间的相互作用可能是可用于靶向金属毒性的重要因素。假设可以通过维持锌等必需微量金属的状态来降低铅的毒性。