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A case of monofocal motor neuropathy with GM1 and GD1b antibodies improved with intravenous immunoglobulin
Journal of Neuroimmunology ( IF 3.3 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.jneuroim.2020.577452
Vittorio Mantero , Paola Basilico , Paolo Borelli , Antonio Cappello , Andrea Salmaggi , Andrea Rigamonti

Multifocal motor neuropathy is a purely motor neuropathy with a probably dysimmune pathogenesis, supported by the presence of anti-GM1 IgM antibodies in about half of the cases. Single nerve involvement allows for diagnosis of possible multifocal motor neuropathy. We present the case of a middle age man presenting with progressive weakness and hypotrophy in the left leg and difficulty in walking, in which we have diagnosed a dysimmune mononeuropathy. Treatment with IVIg was performed with substantial improvement. Although only one nerve is involved, early diagnosis of dysimmune mononeuropathy is important to start IVIg treatment that is often decisive.

中文翻译:

静脉注射免疫球蛋白改善 GM1 和 GD1b 抗体的单灶性运动神经病一例

多灶性运动神经病是一种纯粹的运动神经病,其发病机制可能是免疫失调,大约一半的病例中存在抗 GM1 IgM 抗体。单神经受累可以诊断可能的多灶性运动神经病。我们介绍了一个中年男子的案例,他的左腿出现进行性虚弱和萎缩以及行走困难,我们已诊断出患有免疫失调性单神经病。用 IVIg 进行的治疗得到了显着改善。虽然只涉及一根神经,但免疫异常单神经病的早期诊断对于开始 IVIg 治疗很重要,这通常是决定性的。
更新日期:2021-01-01
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