Conventional wound-dressing materials with structural and functional deficiencies are not effective in promoting wound healing. The development of multifunctional wound dressings is emerging as a promising strategy to accelerate blood coagulation, inhibit bacterial infection, and trigger full-thickness wound into a regenerative process. Herein, multifunctional composite sponges were developed by incorporation of traditional Chinese medicine Kangfuxin (KFX) into alginate (AG)/carboxymethyl chitosan (CMC) via green crosslinking, electrostatic interaction, and freeze-drying methods. It is demonstrated that the AG/CMC/KFX (ACK) sponges exhibit a highly interconnected and porous structure, suitable water vapor transmittance, excellent elastic properties, antibacterial behavior, cytocompatibility, and rapid hemostasis. Further, in a rat full-thickness wounds model, the ACK sponge containing 10% KFX (ACK-10) significantly facilitates wound closure compared to the AC group and ACK sponge containing 5% and 15% KFX. Thus, the multifunctional ACK-10 composite sponge has great promise for the application of full-thickness wound healing.

具有结构和功能缺陷的常规伤口敷料不能有效地促进伤口愈合。多功能伤口敷料的开发正在成为一种有前景的策略，可以加速血液凝固，抑制细菌感染并触发全层伤口进入再生过程。在这里，多功能复合海绵是通过将中成药康福信（KFX）通过海藻酸钠（AG）/羧甲基壳聚糖（CMC）掺入而开发的。绿色交联，静电相互作用和冷冻干燥方法。结果表明，AG / CMC / KFX（ACK）海绵具有高度互连和多孔的结构，合适的水蒸气透过率，出色的弹性，抗菌性能，细胞相容性和快速止血功能。此外，在大鼠全层伤口模型中，与AC组和含有5％和15％KFX的ACK海绵相比，含有10％KFX（ACK-10）的ACK海绵显着促进了伤口闭合。因此，多功能ACK-10复合海绵对全厚度伤口愈合的应用具有广阔的前景。