We investigated HLA class I (HLA-A, -B, and -C) and class II (HLA-DRB1, -DQB1, -DPA1, and -DPB1) alleles by NGS-based typing among 759 Brazilian individuals from three populations in the Rio de Janeiro city based on their self-declared skin color (Caucasian, N = 521, AFND-ID: 3730; Parda, N = 170, AFND-ID: 3728; Black, N = 68, AFND-ID: 3727) to calculate allelic and haplotypic frequencies, plus linkage disequilibrium. Only HLA-DRB1 locus deviated from Hardy-Weinberg equilibrium (in Caucasian and Black populations). The three populations shared the most frequent allele on HLA-A, -C, -DRB1, -DPA1, and -DPB1. Genotype and frequency data are available in the Allele Frequencies Net Database.

我们通过基于 NGS 的分型在来自三个群体的 759 名巴西个体中调查了 HLA I 类（HLA-A、-B 和 -C）和 II 类（HLA-DRB1、-DQB1、-DPA1 和 -DPB1）等位基因。里约热内卢市根据他们自称的肤色（白种人，N = 521，AFND-ID：3730；Parda，N = 170，AFND-ID：3728；黑色，N = 68，AFND-ID：3727）到计算等位基因和单倍型频率，加上连锁不平衡。只有 HLA-DRB1 基因座偏离了 Hardy-Weinberg 平衡（在白种人和黑人群体中）。这三个群体在 HLA-A、-C、-DRB1、-DPA1 和 -DPB1 上共享最常见的等位基因。等位基因频率网络数据库中提供了基因型和频率数据。