Symptomatic dermographism (SD) is the most common form of physical urticaria. So far no promising serum biomarkers for SD have been reported. Recently, microRNAs (miRNAs) have been reported to be serum biomarkers for chronic spontaneous urticaria. However, association of miRNAs with SD remains unclear. We enrolled 55 SD patients and 52 healthy controls in this study. We found that serum expressions of miR-126-3p and miR-16-5p were significantly downregulated in active SD patients and upregulated in remission. The area under the curve values of miR-126-3p (0.769) and miR-16-5p (0.789) showed significant ability to diagnostic SD. Serum level of vascular endothelial growth factor (VEGF)-A, a known target of the two miRNAs, was significantly increased in active SD patients and decreased in remission. Moreover, serum VEGF-A level was inversely correlated with expressions of miR-126-3p and miR-16-5p. Our findings indicate that miR-126-3p and miR-16-5p can serve as potential serum biomarkers for SD.

有症状的皮肤病（SD）是物理性荨麻疹的最常见形式。到目前为止，尚无SD有望的血清生物标志物报道。最近，有报道说microRNA（miRNA）是慢性自发性荨麻疹的血清生物标志物。然而，miRNA与SD的关联仍不清楚。在这项研究中，我们招募了55名SD患者和52名健康对照。我们发现在活跃的SD患者中，miR-126-3p和miR-16-5p的血清表达显着下调，而在缓解时则上调。miR-126-3p（0.769）和miR-16-5p（0.789）曲线值下的面积显示出显着的SD诊断能力。血清血管内皮生长因子（VEGF）-A（两种miRNA的已知靶标）的水平在活跃的SD患者中显着增加，而缓解率则下降。此外，血清VEGF-A水平与miR-126-3p和miR-16-5p的表达呈负相关。我们的发现表明，miR-126-3p和miR-16-5p可以作为SD的潜在血清生物标志物。