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Delivery, Beam and Range Monitoring in Particle Therapy in a Highly Innovative Integrated Design
Frontiers in Physics ( IF 3.1 ) Pub Date : 2020-10-28 , DOI: 10.3389/fphy.2020.566679
L. Bottura , E. Felcini , V. Ferrero , E. Fiorina , V. Monaco , F. Pennazio , G. de Rijk , P. Cerello

The design of a particle therapy system that integrates an innovative beam delivery concept based on a static toroidal gantry and an imaging configuration suitable for beam and online range monitoring is proposed and discussed. Such approach would provide a compact and cost-effective layout, with a highly flexible and fast beam delivery, single particle counting capability for fast measurement of beam fluence and position and a precise real time verification of the compliance between the treatment delivery and its prescription. The gantry configuration is discussed, presenting an analysis of the residual magnetic field in the bore and of the feasibility of irradiating a realistic target volume. Moreover, the expected performance of the PET-based range monitor is assessed through Monte Carlo simulations, showing a precision in the reconstruction of the activity distribution from a clinical treatment plan better than the state-of-the-art devices. The feasibility of the proposed design is then discussed through an assessment of the technological improvements required to actually start the construction and commissioning of a system prototype.



中文翻译:

高度创新的集成设计中的粒子治疗中的输送,束和距离监控

提出并讨论了一种粒子治疗系统的设计,该系统结合了基于静态环形机架的创新射束传输概念和适用于射束和在线范围监视的成像配置。这种方法将提供紧凑且具有成本效益的布局,具有高度灵活且快速的光束传输,单粒子计数功能,可快速测量光束的通量和位置,并实时精确地验证治疗传输与其处方之间的依从性。讨论了龙门架的配置,提出了对孔中残留磁场的分析以及辐照实际目标体积的可行性。此外,通过蒙特卡洛模拟评估了基于PET的距离监测器的预期性能,与最先进的设备相比,从临床治疗计划中重建活动分布的精度更高。然后,通过评估实际开始构建和试运行系统原型所需的技术改进,来讨论所提议设计的可行性。

更新日期:2020-12-01
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