This paper presents autopsy findings of 3 COVID-19 patients randomly selected for post-mortem from two tertiary referral Polish hospitals. Analysis of macroscopic, histopathological findings with clinical features was performed. All 3 deceased patients were Caucasian males (average age 61 years, range from 56 to 68 years). Using real-time polymerase chain reaction assay, the patients were confirmed (antemortem) to have severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Two patients were obese, and 1 patient had type 2 diabetes mellitus. The medical history of 1 patient included hemorrhagic pancreatitis, gangrenous cholecystitis, Acinetobacter baumanii sepsis, and cholecystectomy. Pulmonary embolism was diagnosed in 2 patients. At autopsy, in 1 case, the lungs showed bilateral interstitial pneumonia with diffuse alveolar damage (DAD), while in another case, interstitial pulmonary lymphoid infiltrates and enlarged atypical pneumocytes were present but without DAD. Microthrombi in lung vessels and capillaries were observed in 2 cases. This study revealed thrombotic complications of COVID-19 and interstitial pneumonia with DAD presence as the main autopsy findings in patients with SARS-CoV-2 infection that was confirmed antemortem with molecular tests. Autopsy studies using tissue sections handled in accordance with SARS-CoV-2 biosafety guidelines are urgently needed, especially in the case of subjects who were below the age of 60.

中文翻译：

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COVID-19 尸检：来自波兰的病例系列

本文介绍了从波兰两家三级转诊医院随机选择的 3 名 COVID-19 患者的尸检结果。对具有临床特征的宏观组织病理学发现进行分析。所有 3 名死者均为白人男性（平均年龄 61 岁，范围为 56 至 68 岁）。使用实时聚合酶链反应测定，患者被确认（​​生前）患有严重急性呼吸系统综合症冠状病毒 2（SARS-CoV-2）感染。2 名患者肥胖，1 名患者患有 2 型糖尿病。1 例患者的病史包括出血性胰腺炎、坏疽性胆囊炎、鲍曼不动杆菌败血症和胆囊切除术。2 例患者被诊断为肺栓塞。尸检时，1例，肺部显示双侧间质性肺炎伴弥漫性肺泡损伤 (DAD)，而在另一例中，存在间质性肺淋巴浸润和非典型肺细胞增大但无 DAD。肺血管及毛细血管微血栓2例。这项研究揭示了 COVID-19 的血栓并发症和伴有 DAD 的间质性肺炎是 SARS-CoV-2 感染患者的主要尸检结果，并在死前通过分子检测证实。迫切需要使用按照 SARS-CoV-2 生物安全指南处理的组织切片进行尸检研究，尤其是对于 60 岁以下的受试者。肺血管及毛细血管微血栓2例。这项研究揭示了 COVID-19 的血栓并发症和伴有 DAD 的间质性肺炎是 SARS-CoV-2 感染患者的主要尸检结果，并在死前通过分子检测证实。迫切需要使用按照 SARS-CoV-2 生物安全指南处理的组织切片进行尸检研究，尤其是对于 60 岁以下的受试者。肺血管及毛细血管微血栓2例。这项研究揭示了 COVID-19 的血栓并发症和伴有 DAD 的间质性肺炎是 SARS-CoV-2 感染患者的主要尸检结果，并在死前通过分子检测证实。迫切需要使用按照 SARS-CoV-2 生物安全指南处理的组织切片进行尸检研究，尤其是对于 60 岁以下的受试者。