Tetrahedron ( IF 2.1 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.tet.2020.131801 Sasadhar Majhi , Debjit Das
Natural products and their semisynthetic derivatives continue to be an important source of potential drug leads. Natural products and their analogues structures possess the characteristics of high chemical diversity, zenith biochemical specificity, and other significant molecular activities as well as pharmacological properties that create them favorably as lead structures for new drug discovery and continue to motivate novel inventions in medicine, chemistry, and biology. Natural products were employed as very good starting materials for analogue design and synthesis as semisynthetic derivatives exhibit higher biological activities in several cases. Such beneficial quality of semisynthetic derivatives as a whole have motivated the organic chemist and biological community to explore the application of semisynthetic derivatives in more heights and as a result, the present review is aimed to offer an overview of natural sources of the starting natural compounds, semisynthesis and biological activities of semisynthetic derivatives during the last decade.
中文翻译:
天然产物的化学衍生化:半合成和药理学方面-十年更新
天然产物及其半合成衍生物仍然是潜在药物线索的重要来源。天然产物及其类似物结构具有高度化学多样性,天顶生化特异性和其他重要分子活性以及药理特性的特征,这些特性使其很容易成为新药发现的先导结构,并继续激发着医学,化学,和生物学。天然产物被用作类似物设计和合成的很好的起始原料,因为在某些情况下半合成衍生物具有更高的生物活性。