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Surviving under pollution stress: Antibacterial and antifungal activities of the Oyster species (Magallana bilineata and Magallana cuttackensis)
Fish & Shellfish Immunology ( IF 4.7 ) Pub Date : 2020-11-30 , DOI: 10.1016/j.fsi.2020.11.021
Malik Wajid Hussain Chan , Khwaja Ali Hasan , Danilo Balthazar-Silva , Muhammad Asghar , Zulfiqar Ali Mirani

Antibiotic effectively controls the bacterial and fungal infections. Pathogens developing multi-drug resistance are a global health concern, which necessitate developing new molecules to overcome the resistance dilemma. This study explores the intrinsic ability of marine oysters synthesizing bioactive compounds. The tissue extracts prepared in n-hexane from two oysters, Magallana bilineata and Magallana cuttackensis compared for broad spectral antimicrobial activates against the fungal, Gram positive and negative pathogens. Regardless, both the species tolerated the same pollution indices; the M. bilineata exhibits stronger antimicrobial activities as compared to M. cuttackensis. M. bilineata potentially inhibited the bacterial growth with minimal inhibitory concentration (0.75–20 μg/ml) and fungal pathogens (0.75–5 μg/ml) as compared to ciprofloxacin and miconazole. Inhibitory potential complimented with reduce bactericidal and fungicidal concentrations required to observed susceptible zone of inhibition (ZOI). The inhibition augmented with increased antimicrobial index (AMI) and total activity index (TAI) against the human pathogen than those of M. cuttackensis. It is widely acknowledged that there is a need to develop novel antimicrobial agents to minimize the threat of emerging multiple antimicrobial resistant pathogens. Therefore, the oysters surviving in the pollution stress modulate the physiological and immune response may exploit to develop potential antibiotics.



中文翻译:

在污染胁迫下生存:牡蛎种(Magallana bilineataMagallana cuttackensis)的抗菌和抗真菌活性

抗生素可有效控制细菌和真菌感染。发展多药耐药性的病原体是全球健康问题,因此有必要开发新的分子来克服耐药性的困境。这项研究探索了海洋牡蛎合成生物活性化合物的内在能力。用正己烷从两只牡蛎Magallana bilineataMagallana cuttackensis制备的组织提取物具有广谱抗菌活性,可针对真菌,革兰氏阳性和阴性病原体进行比较。不管怎样,这两个物种都可以忍受相同的污染指数。所述M.天蛾相比表现出更强的抗菌活性M. cuttackensis双线莲与环丙沙星和咪康唑相比,以最小抑菌浓度(0.75–20μg/ ml)和真菌病原体(0.75–5μg/ ml)潜在地抑制了细菌的生长。抑制潜能与降低观察到的敏感抑制区(ZOI)所需的杀菌和杀真菌浓度相称。该抑制作用比抗割胶粘菌增加了对人类病原体的增加的抗菌指数(AMI)和总活性指数(TAI)。众所周知,需要开发新的抗微生物剂以使出现的多种抗微生物抗性病原体的威胁最小化。因此,在污染胁迫下存活的牡蛎可以调节生理和免疫反应,从而开发出潜在的抗生素。

更新日期:2020-12-14
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