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Atopic Dermatitis and Psoriasis as Overlapping Syndromes
Mediators of Inflammation ( IF 4.6 ) Pub Date : 2020-11-28 , DOI: 10.1155/2020/7527859 A Bozek 1 , M Zajac 2, 3 , M Krupka 1
Mediators of Inflammation ( IF 4.6 ) Pub Date : 2020-11-28 , DOI: 10.1155/2020/7527859 A Bozek 1 , M Zajac 2, 3 , M Krupka 1
Affiliation
Background/Objectives. Cooccurrence of atopic dermatitis (AD) and psoriasis (PS) is not common. However, both diseases are still of interest because of their comprehensive and diverse mechanisms. This study aimed to present the clinical and immunological profiles of patients with concomitant AD and PS and compare them with those of patients with only one of the diseases. Methods. In this observational study, 38 children with concomitant AD and PS with a mean age of yrs were compared with 41 similar patients with AD only ( yrs) and 28 patients with PS only ( yrs). All patients underwent dermatological examinations, including determination of SCORAD and PASI scores. TNF-α, IFN-γ, IL-2, IL-4, IL-5, IL-6, IL-8, IL-12, IL-17, IL-18, IL-22, I:-33, and TARC/CCL17 were measured by ELISA according to the manufacturer’s instructions. Results. Patients with concomitant AD and PS were frequently boys and overweight and had skin lesions equally distributed throughout the body. Children with concomitant AD and PS were more likely to report a family history of atopic disease than children with only AD or PS, and those with AD were more likely to report a family history of atopic disease than those with PS. Significant differences were observed in the concentration of IL-17 between patients with AD and PS and those with only AD or PS: pg/ml vs. pg/ml; and pg/ml vs. pg/ml, respectively (PD vs. AD, ; PD vs. PS, ). Conclusions. AD and PS can coexist. The role of T helper 17 cells may be more essential than believed.
中文翻译:
特应性皮炎和银屑病作为重叠综合征
背景/目标。特应性皮炎 (AD) 和银屑病 (PS) 不常见。然而,这两种疾病仍然受到关注,因为它们具有全面而多样的机制。本研究旨在展示同时患有 AD 和 PS 的患者的临床和免疫学特征,并将其与仅患有其中一种疾病的患者进行比较。方法。在这项观察性研究中,38 名伴有 AD 和 PS 的儿童平均年龄为 yrs 与 41 名类似的 AD 患者进行了比较( 年)和 28 名仅患有 PS 的患者( 年)。所有患者都接受了皮肤病学检查,包括 SCORAD 和 PASI 评分的测定。TNF - α、IFN- γ、IL-2、IL-4、IL-5、IL-6、IL-8、IL-12、IL-17、IL-18、IL-22、I:-33 和根据制造商的说明通过 ELISA 测量 TARC/CCL17。结果. 伴有 AD 和 PS 的患者通常是男孩和超重,并且皮肤损伤均匀分布在全身。与仅患有 AD 或 PS 的儿童相比,同时患有 AD 和 PS 的儿童更有可能报告特应性疾病的家族史,而患有 AD 的儿童比患有 PS 的儿童更有可能报告特应性疾病的家族史。AD 和 PS 患者与仅 AD 或 PS 患者的 IL-17 浓度存在显着差异: pg/ml 对比 皮克/毫升;和 pg/ml 对比 pg/ml,分别(PD 与 AD,; PD 与 PS,)。 结论。AD和PS可以共存。T 辅助 17 细胞的作用可能比人们认为的更重要。
更新日期:2020-12-01
中文翻译:
特应性皮炎和银屑病作为重叠综合征
背景/目标。特应性皮炎 (AD) 和银屑病 (PS) 不常见。然而,这两种疾病仍然受到关注,因为它们具有全面而多样的机制。本研究旨在展示同时患有 AD 和 PS 的患者的临床和免疫学特征,并将其与仅患有其中一种疾病的患者进行比较。方法。在这项观察性研究中,38 名伴有 AD 和 PS 的儿童平均年龄为 yrs 与 41 名类似的 AD 患者进行了比较( 年)和 28 名仅患有 PS 的患者( 年)。所有患者都接受了皮肤病学检查,包括 SCORAD 和 PASI 评分的测定。TNF - α、IFN- γ、IL-2、IL-4、IL-5、IL-6、IL-8、IL-12、IL-17、IL-18、IL-22、I:-33 和根据制造商的说明通过 ELISA 测量 TARC/CCL17。结果. 伴有 AD 和 PS 的患者通常是男孩和超重,并且皮肤损伤均匀分布在全身。与仅患有 AD 或 PS 的儿童相比,同时患有 AD 和 PS 的儿童更有可能报告特应性疾病的家族史,而患有 AD 的儿童比患有 PS 的儿童更有可能报告特应性疾病的家族史。AD 和 PS 患者与仅 AD 或 PS 患者的 IL-17 浓度存在显着差异: pg/ml 对比 皮克/毫升;和 pg/ml 对比 pg/ml,分别(PD 与 AD,; PD 与 PS,)。 结论。AD和PS可以共存。T 辅助 17 细胞的作用可能比人们认为的更重要。