Background

Ectopic fat obesity and triglycerides are risk factors for diabetes and multiple cardiovascular diseases. However, there have been limited studies on the association between triglycerides and ectopic fat obesity. The purpose of this study was to explore the association between triglycerides and ectopic fat obesity.

Methods and results

In this cross-sectional study, we retrospectively analyzed 15464 adult participants recruited by Murakami Memorial Hospital (8430 men and 7034 women, average age of 43.71 ± 8.90). All patients were divided into two groups according to the threshold used to diagnose hypertriglyceridemia. The logistic regression model was used to analyze the association between triglycerides and the risk of ectopic fat obesity, and the generalized additive model was used to identify the nonlinear association. In this study population, the prevalence of ectopic fat obesity was 17.73%. After adjusting other covariables, triglycerides were positively correlated with the risk of ectopic fat obesity (OR: 1.54, 95% CI:1.41–1.69, P<0.0001). Through smooth curve fitting, we found that there was an inverted U-shaped curve association between triglycerides and ectopic fat obesity. This association remained unchanged even if the adjusted covariables were removed from the model, and the inflection point of the curve was 3.98. When triglyceride levels were ≤3.98, triglycerides were positively correlated with the risk of ectopic fat obesity (OR:1.784, 95% CI:1.611–1.975, P<0.0001). When triglyceride levels were >3.98 (right side of the inflection point), there was a negative correlation (OR:0.519, 95% CI:0.333–0.810, P = 0.0039).

Conclusions

Our research showed that there is a significant association between triglycerides and ectopic fat obesity. This relation is not a simple linear relationship but instead an inverted U-shaped curve association.

中文翻译：

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甘油三酸酯与异位肥胖之间的关联：倒U形曲线

背景

异位肥胖症和甘油三酸酯是糖尿病和多种心血管疾病的危险因素。然而，关于甘油三酸酯和异位脂肪肥胖之间关系的研究很少。这项研究的目的是探讨甘油三酸酯与异位脂肪肥胖之间的关系。

方法与结果

在这项横断面研究中，我们回顾性分析了村上纪念医院招募的15464名成人受试者（男性8430名，女性7034名，平均年龄43.71±8.90）。根据诊断高甘油三酯血症的阈值将所有患者分为两组。使用logistic回归模型分析甘油三酸酯与异位脂肪肥胖风险之间的关联，并使用广义加性模型识别非线性关联。在该研究人群中，异位肥胖的患病率为17.73％。调整其他协变量后，甘油三酸酯与异位肥胖的风险呈正相关（OR：1.54，95％CI：1.41-1.69，P<0.0001）。通过平滑曲线拟合，我们发现甘油三酸酯和异位肥胖之间存在倒U型曲线关联。即使从模型中删除了调整后的协变量，该关联仍保持不变，曲线的拐点为3.98。当甘油三酸酯水平≤3.98时，甘油三酸酯与异位肥胖的风险呈正相关（OR：1.784，95％CI：1.611–1.975，P <0.0001）。当甘油三酸酯水平> 3.98（拐点右侧）时，呈负相关（OR：0.519，95％CI：0.333–0.810，P = 0.0039）。

结论

我们的研究表明，甘油三酸酯与异位脂肪肥胖之间存在显着关联。该关系不是简单的线性关系，而是倒U形曲线关联。