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Effective control of SARS-CoV-2 transmission in Wanzhou, China
Nature Medicine ( IF 82.9 ) Pub Date : 2020-11-30 , DOI: 10.1038/s41591-020-01178-5
Qiuling Shi , Yaoyue Hu , Bin Peng , Xiao-Jun Tang , Wei Wang , Kun Su , Chao Luo , Bo Wu , Fan Zhang , Yong Zhang , Benjamin Anderson , Xiao-Ni Zhong , Jing-Fu Qiu , Cheng Yong Yang , Ai-Long Huang

The effectiveness of control measures to contain coronavirus disease 2019 (COVID-19) in Wanzhou, China was assessed. Epidemiological data were analyzed for 183 confirmed COVID-19 cases and their close contacts from five generations of transmission of severe acute respiratory syndrome coronavirus 2 throughout the entire COVID-19 outbreak in Wanzhou. Approximately 67.2% and 32.8% of cases were symptomatic and asymptomatic, respectively. Asymptomatic and presymptomatic transmission accounted for 75.9% of the total recorded transmission. The reproductive number was 1.64 (95% confidence interval: 1.16–2.40) for G1-to-G2 transmission, decreasing to 0.31–0.39 in later generations, concomitant with implementation of rigorous control measures. Substantially higher infection risk was associated with contact within 5 d after the infectors had been infected, frequent contact and ≥8 h of contact duration. The spread of COVID-19 was effectively controlled in Wanzhou by breaking the transmission chain through social distancing, extensive contact tracing, mass testing and strict quarantine of close contacts.

更新日期:2020-12-01
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