Abstract The purpose of this study was to investigate the effects of sodium butyrate as a substitute for antibiotics on the production performance and intestinal barrier of meat rabbits. Six hundred healthy weaned rabbits were randomly divided into three groups (40 replicates per group): fed a basal diet (control), fed a basal diet containing 0.5% sodium butyrate (sodium butyrate), or fed a basal diet containing 0.004% antibiotics (antibiotic). The trial included 7 days of adaptation and 28 days of testing. After adding sodium butyrate to the feed, the mortality and diarrhoea rates of the weaned meat rabbits were reduced, and the composition of their intestinal flora was improved. Treatment significantly increased the villus height of the ileum (p < .05), decreased the crypt depth of the jejunum, and increased the V/C ratio of intestinal tissue. The contents of IL-4, IFN-γ and SIgA in the intestinal tissue were significantly increased, indicating improvement of the intestinal immune barrier. The expression of occludin in the duodenum also increased significantly. To sum up, sodium butyrate can be added to the diet of growing meat rabbits instead of antibiotics. The physical barrier, immune barrier and microbial barrier of rabbit intestine were improved. Rabbit farmers can use sodium butyrate to prepare a new type of eco-friendly feed. Highlights Antibiotics in rabbit feed can be replaced by sodium butyrate. The addition of sodium butyrate to feed can reduce the mortality and diarrhoea rate of rabbits. Sodium butyrate can improve the intestinal barrier of rabbits.

中文翻译：

---

丁酸钠改善兔肠道屏障

摘要 本研究旨在研究丁酸钠替代抗生素对肉兔生产性能和肠道屏障的影响。600只健康断奶兔随机分为三组（每组40个重复）：饲喂基础日粮（对照），饲喂含0.5%丁酸钠（丁酸钠）的基础日粮，或饲喂含0.004%抗生素的基础日粮（抗生素）。试验包括 7 天的适应和 28 天的测试。在饲料中添加丁酸钠后，断奶肉兔的死亡率和腹泻率降低，肠道菌群组成得到改善。治疗显着增加了回肠的绒毛高度（p < .05），减少了空肠的隐窝深度，并增加了肠组织的 V/C 比。肠道组织中IL-4、IFN-γ和SIgA含量显着升高，表明肠道免疫屏障得到改善。十二指肠中occludin的表达也显着增加。综上所述，在生长肉兔的饮食中可以添加丁酸钠代替抗生素。提高兔肠道的物理屏障、免疫屏障和微生物屏障。兔农可以使用丁酸钠制备新型环保饲料。亮点兔饲料中的抗生素可以用丁酸钠代替。在饲料中添加丁酸钠可以降低家兔的死亡率和腹泻率。丁酸钠可改善家兔的肠道屏障。表明肠道免疫屏障的改善。occludin 在十二指肠中的表达也显着增加。综上所述，生长肉兔的饮食中可以添加丁酸钠代替抗生素。提高兔肠道的物理屏障、免疫屏障和微生物屏障。养兔户可以使用丁酸钠制备新型环保饲料。亮点兔饲料中的抗生素可以用丁酸钠代替。在饲料中添加丁酸钠可以降低家兔的死亡率和腹泻率。丁酸钠可改善家兔的肠道屏障。表明肠道免疫屏障的改善。occludin 在十二指肠中的表达也显着增加。综上所述，在生长肉兔的饮食中可以添加丁酸钠代替抗生素。提高兔肠道的物理屏障、免疫屏障和微生物屏障。养兔户可以使用丁酸钠制备新型环保饲料。亮点兔饲料中的抗生素可以用丁酸钠代替。在饲料中添加丁酸钠可以降低家兔的死亡率和腹泻率。丁酸钠可改善家兔的肠道屏障。提高兔肠道的免疫屏障和微生物屏障。养兔户可以使用丁酸钠制备新型环保饲料。亮点兔饲料中的抗生素可以用丁酸钠代替。在饲料中添加丁酸钠可以降低家兔的死亡率和腹泻率。丁酸钠可改善家兔的肠道屏障。提高兔肠道的免疫屏障和微生物屏障。养兔户可以使用丁酸钠制备新型环保饲料。亮点兔饲料中的抗生素可以用丁酸钠代替。在饲料中添加丁酸钠可以降低家兔的死亡率和腹泻率。丁酸钠可改善家兔的肠道屏障。