ABSTRACT

Introduction

Porcine reproductive and respiratory syndrome (PRRS) is an infectious disease of swine characterized by respiratory disorders in growing and finishing pigs and reproductive failure in pregnant sows. PRRSV has been recognized as one of the most economically significant pathogens affecting the global pig industry.

Areas covered

Currently, commercially available vaccines, including traditional killed virus (KV) vaccines and modified live virus (MLV) vaccines, are the cardinal approaches to prevent and control porcine reproductive and respiratory syndrome virus (PRRSV) infection. However, the protective efficacy of these vaccines is not satisfactory, resulting in the continuous evolution and recurrent appearance of the virus as well as the emergence of new variants. A safe and effective vaccine against PRRSV is in dire need. Here, we review the research progress in recent years in the development and use of PRRSV as a viral vector to express foreign genes, and their potential application in gene delivery and vaccine development.

Expert opinion

The potential of using PRRSV-based vectors to express multiple antigens would be particularly instrumental for the development of a new generation of multivalent vaccines against PRRSV and other porcine viruses.

中文翻译：

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猪繁殖与呼吸综合征病毒作为外源基因表达和传递的病毒载体的研究进展

摘要

介绍

猪繁殖与呼吸综合症（PRRS）是一种猪的传染病，其特征是生长和肥育猪的呼吸系统疾病和怀孕母猪的生殖衰竭。PRRSV被公认为是影响全球养猪业的最具经济意义的病原体之一。

覆盖区域

当前，商业上可买到的疫苗包括传统的灭活病毒（KV）疫苗和改良的活病毒（MLV）疫苗，是预防和控制猪繁殖与呼吸综合征病毒（PRRSV）感染的主要方法。然而，这些疫苗的保护功效不令人满意，导致病毒的不断进化和反复出现以及新变体的出现。迫切需要安全有效的抗PRRSV疫苗。在这里，我们回顾了近年来在PRRSV作为表达外源基因的病毒载体的开发和使用方面的研究进展，及其在基因传递和疫苗开发中的潜在应用。

专家意见

使用基于PRRSV的载体表达多种抗原的潜力将特别有助于开发针对PRRSV和其他猪病毒的新一代多价疫苗。