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The Intestinal Microbiota and Colorectal Cancer
Frontiers in Immunology ( IF 7.3 ) Pub Date : 2020-11-02 , DOI: 10.3389/fimmu.2020.615056
Yiwen Cheng 1 , Zongxin Ling 1 , Lanjuan Li 1
Affiliation  

The intestinal microbiota, composed of a large population of microorganisms, is often considered a “forgotten organ” in human health and diseases. Increasing evidence indicates that dysbiosis of the intestinal microbiota is closely related to colorectal cancer (CRC). The roles for intestinal microorganisms that initiated and facilitated the CRC process are becoming increasingly clear. Hypothesis models have been proposed to illustrate the complex relationship between the intestinal microbiota and CRC. Recent studies have identified Streptococcus bovis, enterotoxigenic Bacteroides fragilis, Fusobacterium nucleatum, Enterococcus faecalis, Escherichia coli, and Peptostreptococcus anaerobius as CRC candidate pathogens. In this review, we summarized the mechanisms involved in microbiota-related colorectal carcinogenesis, including inflammation, pathogenic bacteria, and their virulence factors, genotoxins, oxidative stress, bacterial metabolites, and biofilm. We also described the clinical values of intestinal microbiota and novel strategies for preventing and treating CRC.



中文翻译:

肠道菌群与大肠癌

肠道微生物群由大量微生物组成,通常被认为是人类健康和疾病中的“被遗忘的器官”。越来越多的证据表明,肠道菌群失调与大肠癌(CRC)密切相关。引发和促进CRC过程的肠道微生物的作用越来越明确。提出了假设模型来说明肠道菌群和CRC之间的复杂关系。最近的研究已经确定牛链球菌肠毒素 脆弱拟杆菌核梭菌粪肠球菌大肠杆菌厌氧消化链球菌作为CRC候选病原体。在这篇综述中,我们总结了与微生物群相关的大肠癌发生的机制,包括炎症,致病细菌及其毒力因子,遗传毒素,氧化应激,细菌代谢产物和生物膜。我们还描述了肠道菌群的临床价值以及预防和治疗CRC的新策略。

更新日期:2020-12-01
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