Wnt signaling is one of a few conserved pathways that control diverse aspects of development and morphogenesis in all metazoan species. Endocytosis is a key mechanism that regulates the secretion and graded extracellular distribution of Wnt glycoproteins from the source cells, as well as Wnt signal transduction in the receiving cells. However, controversies exist regarding the requirement of clathrin-dependent endocytosis in Wnt signaling. Various lines of evidence from recent studies suggest that Wnt-β-catenin signaling is also involved in the regulation of cellular stress responses in adulthood, a role that is beyond its canonical functions in animal development. In this review, we summarize recent advances in the molecular and cellular mechanisms by which endocytosis modulates Wnt signaling. We also discuss how Wnt signaling could be repurposed to regulate mitochondrial stress response in the nematode Caenorhabditis elegans. This article is protected by copyright. All rights reserved.

中文翻译：

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Wnt 信号传导和内吞作用：压力反应的机制、争议和影响

Wnt 信号传导是控制所有后生动物物种发育和形态发生的不同方面的少数保守途径之一。内吞作用是调节源细胞 Wnt 糖蛋白的分泌和分级细胞外分布以及接收细胞中 Wnt 信号转导的关键机制。然而，关于 Wnt 信号传导中网格蛋白依赖性内吞作用的要求存在争议。最近研究的各种证据表明，Wnt-β-catenin 信号传导也参与了成年期细胞应激反应的调节，这一作用超出了其在动物发育中的典型功能。在这篇综述中，我们总结了内吞作用调节 Wnt 信号传导的分子和细胞机制的最新进展。我们还讨论了如何重新利用 Wnt 信号来调节线虫秀丽隐杆线虫的线粒体应激反应。本文受版权保护。版权所有。