Reported here is a concise total synthesis of (−)‐berkelic acid in eight linear steps. This synthesis features a Catellani reaction/oxa‐Michael cascade for the construction of the isochroman scaffold, a one‐pot deprotection/spiroacetalization operation for the formation of the tetracyclic core structure, and a late‐stage Ni‐catalyzed reductive coupling for the introduction of the lateral chain. Notably, four stereocenters are established from a single existing chiral center with excellent stereocontrol during the deprotection/spiroacetalization process. Stereocontrol of the intriguing deprotection/spiroacetalization process is supported by DFT calculations.

中文翻译：

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简明全合成（-）-铍酸

此处报告的是八个线性步骤的简明全合成（-）-伯酸。该合成的特征是用于构建异色满骨架的Catellani反应/ oxa-Michael级联反应，用于形成四环核心结构的一锅脱保护/螺缩醛化操作以及用于引入Ni的后期Ni催化还原偶联。横向链。值得注意的是，在脱保护/螺缩醛化过程中，从一个现有的手性中心建立了四个立体中心，并具有出色的立体控制。DFT计算支持对有趣的脱保护/螺缩醛化过程的立体控制。