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Dysmorphism and major anomalies are a main predictor of survival in newborns admitted to the neonatal intensive care unit in the Democratic Republic of Congo
American Journal of Medical Genetics Part A ( IF 2 ) Pub Date : 2020-11-27 , DOI: 10.1002/ajmg.a.61987
Gerrye Mubungu 1, 2, 3 , Prince Makay 1, 2 , Aimé Lumaka 1, 2, 4, 5 , Nono Mvuama 6 , Dahlie Tshika 1, 2 , Bruno-Paul Tady 2 , Thérèse Biselele 2 , Mathieu Roelants 7 , Prosper Lukusa Tshilobo 1, 2, 3, 5 , Koenraad Devriendt 3
Affiliation  

In Central‐Africa, neonatal infections, asphyxia and prematurity are main reasons for admission to the neonatal intensive care unit and major determinants of newborn survival. Also, the outcome of newborns with congenital anomalies is expected to be poor, due to a lack of state‐of‐the art care. We conducted a study of 102 newborns recruited in the Neonatal Intensive Care Unit (NICU) at the University Hospitals of Kinshasa, DR Congo, to assess the impact of congenital anomalies. The presence of a major anomaly was associated with a hazard ratio of death of 13.2 (95%CI: 3.7–46.7, p < .001). In addition, the presence of three or more minor anomalies was associated with a 4.5‐fold increased risk of death (95%CI: 1.1–18.6, p = .04). We conclude that like major anomalies, the presence of three or more minor anomalies should also be given particular attention and that the evaluation of dysmorphism should be promoted in NICU.

中文翻译:

畸形和严重异常是刚果民主共和国新生儿重症监护病房收治的新生儿生存的主要预测指标

在中非,新生儿感染,窒息和早产是进入新生儿重症监护病房的主要原因,也是新生儿存活率的主要决定因素。此外,由于缺乏最新的护理,预计先天性异常的新生儿的结局会很差。我们对刚果民主共和国金沙萨大学医院新生儿重症监护室(NICU)招募的102名新生儿进行了研究,以评估先天性异常的影响。重大异常的出现与死亡的危险比为13.2(95%CI:3.7-46.7,p  <.001)。此外,三个或三个以上轻微异常的出现与死亡风险增加了4.5倍相关(95%CI:1.1-18.6,p= .04)。我们得出的结论是,像主要异常一样,也应特别注意三个或更多次要异常的存在,并应在NICU中促进对同态性的评估。
更新日期:2021-01-12
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