Abstract This manuscript is related to the study of volumetric and micellar properties of metformin hydrochloride (Met HCl) in methanol in temperature range of (288.15-318.15) K. Conductometric and refractive index data was used to find CMC of drug. From conductometric data various thermodynamic variables were calculated which include free energy of micellization, entropy of micellization and enthalpy of micellization. Density measurements of different drug solutions at specified temperatures were utilized for the calculation of apparent molar volume, partial molar volume, Hepler's constant and partial molar expansivity. These parameters are important for getting an understanding about different types of interaction of drug in solution. Met HCl showed strong solvophobic than electrostatic interaction with methanol and had a structure promoting effect on it which was apparent from positive value of partial molar volume, Hepler's constant and partial molar expansivity. Micellization process was spontaneous, endothermic and resulted in increase in entropy of system because Gibbs energy change was negative, enthalpy change and entropy changes were positive.

中文翻译：

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(288.15-318.15)K温度范围内盐酸二甲双胍在甲醇中的体积和聚集特性

摘要 本手稿涉及在 (288.15-318.15) K 温度范围内盐酸二甲双胍 (Met HCl) 在甲醇中的体积和胶束特性的研究。电导和折光率数据用于确定药物的 CMC。从电导数据计算了各种热力学变量，包括胶束化自由能、胶束化熵和胶束化焓。在指定温度下对不同药物溶液的密度测量被用于计算表观摩尔体积、偏摩尔体积、Hepler 常数和偏摩尔膨胀率。这些参数对于了解溶液中药物的不同类型的相互作用很重要。Met HCl 显示出强于与甲醇的静电相互作用的疏溶剂性，并对其具有结构促进作用，这从偏摩尔体积的正值、Hepler 常数和偏摩尔膨胀率中可以看出。由于吉布斯能量变化为负，焓变和熵变为正，胶束化过程是自发的、吸热的，导致系统熵增加。