Iron stores at birth in a full term normal birth weight birth cohort with a low level of inflammation.,Bioscience Reports

当前位置： X-MOL 学术 › Biosci. Rep. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Iron stores at birth in a full term normal birth weight birth cohort with a low level of inflammation.
Bioscience Reports ( IF 4 ) Pub Date : 2020-10-27 , DOI: 10.1042/bsr20202853
Joy Y. Zhang ₁ , Jing Wang ₂ , Qinsheng Lu ₁ , Meizhen Tan ₂ , Ru Wei ₂ , Gendie E. Lash ₁

Affiliation

Iron stores at birth are essential to meet iron needs during the first 4-6 months of life. This study aimed to investigate iron stores in normal birth weight, healthy, term neonates. Umbilical cord blood samples were collected from apparently normal singleton vaginal deliveries (n=854). Subjects were screened and excluded if C-reactive protein (CRP) >5 mg/L or α1-acid glycoprotein (AGP) >1 g/L, preterm (<37 complete weeks), term <2500g or term >4000g. In total 762 samples were included in the study. Serum ferritin, soluble transferrin receptor (sTfR), hepcidin, and erythropoietin (EPO) were measured in umbilical cord blood samples; total body iron (TBI) (mg/kg) was calculated using sTfR and ferritin concentrations. 19.8% newborns were iron deficient (ferritin <35 μg/L) and an additional 46.6% had insufficient iron stores (ferritin <76 μg/L). There was a positive association between serum ferritin and sTfR, hepcidin and EPO. Gestational age was positively associated with ferritin, sTfR, EPO and hepcidin. In conclusion, we demonstrate a high prevalence of insufficient iron stores in a Chinese birth cohort. The value of cord sTfR and TBI in the assessment of iron status in the newborn is questionable, and reference ranges need to be established.

更新日期：2020-12-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>