Significance: Optical coherence tomography (OCT) has been widely used in clinical studies. However, the image quality of OCT decreases with increasing imaging depth since the light is rapidly attenuated in biological tissues. Aim: We present a compensation approach to preserve weak high-frequency signals from deep structures and compress the dynamic range of the detected signal for superior analog-to-digital conversion and image display capability. Approach: A homemade frequency gain compensation amplifier is designed and fabricated to amplify the electrical signal from a balanced photodetector and compensate for the signal attenuation in swept-source OCT (SSOCT). Results: It is demonstrated in imaging various objects that this cost-efficient technique effectively enhances the contrast of the deep tissue image. Conclusions: A frequency gain compensation amplifier is designed and used to compress the dynamic range of the electrical signal detected by the photodetector of an SSOCT system, which enables weak signals from deep structures to be acquired by the ADC and displayed with enhanced local contrast.

中文翻译：

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具有频率增益补偿放大器的扫频源光学相干断层扫描系统中的动态范围压缩和对比度增强

意义：光学相干断层扫描（OCT）已广泛应用于临床研究。然而，OCT 的图像质量随着成像深度的增加而降低，因为光在生物组织中会迅速衰减。目的：我们提出了一种补偿方法，以保留来自深层结构的微弱高频信号，并压缩检测到的信号的动态范围，以实现卓越的模数转换和图像显示能力。方法：设计并制造自制的频率增益补偿放大器，以放大来自平衡光电探测器的电信号并补偿扫频源 OCT (SSOCT) 中的信号衰减。结果：在对各种物体进行成像时证明，这种具有成本效益的技术有效地增强了深部组织图像的对比度。结论：