Our aim was to analyze whether endotoxemia, i.e. translocation of LPS to circulation, is reflected in the serum metabolic profile in a general population and in participants with cardiometabolic disorders. We investigated three Finnish cohorts separately and in a meta-analysis (n = 7178), namely population-based FINRISK97, FinnTwin16 consisting of young adult twins, and Parogene, a random cohort of cardiac patients. Endotoxemia was determined as serum LPS activity and metabolome by an NMR platform. Potential effects of body mass index (BMI), smoking, metabolic syndrome (MetS), and coronary heart disease (CHD) status were considered. Endotoxemia was directly associated with concentrations of VLDL, IDL, LDL, and small HDL lipoproteins, VLDL particle diameter, total fatty acids (FA), glycoprotein acetyls (GlycA), aromatic and branched-chain amino acids, and Glc, and inversely associated with concentration of large HDL, diameters of LDL and HDL, as well as unsaturation degree of FAs. Some of these disadvantageous associations were significantly stronger in smokers and subjects with high BMI, but did not differ between participants with different CHD status. In participants with MetS, however, the associations of endotoxemia with FA parameters and GlycA were particularly strong. The metabolic profile in endotoxemia appears highly adverse, involving several inflammatory characters and risk factors for cardiometabolic disorders.

我们的目的是分析内毒素血症，即 LPS 易位至循环，是否反映在一般人群和心脏代谢疾病参与者的血清代谢特征中。我们分别在荟萃分析中调查了三个芬兰队列（n = 7178)，即基于人群的 FINRISK97、由年轻双胞胎组成的 FinnTwin16 和 Parogene，心脏病患者的随机队列。内毒素血症通过 NMR 平台确定为血清 LPS 活性和代谢组。考虑了体重指数 (BMI)、吸烟、代谢综合征 (MetS) 和冠心病 (CHD) 状态的潜在影响。内毒素血症与 VLDL、IDL、LDL 和小 HDL 脂蛋白、VLDL 粒径、总脂肪酸 (FA)、糖蛋白乙酰基 (GlycA)、芳香族和支链氨基酸以及 Glc 的浓度直接相关，与高密度脂蛋白的浓度、低密度脂蛋白和高密度脂蛋白的直径以及脂肪酸的不饱和度。其中一些不利的关联在吸烟者和 BMI 高的受试者中明显更强，但在不同冠心病状态的参与者之间没有差异。然而，在 MetS 参与者中，内毒素血症与 FA 参数和 GlycA 的关联特别强。内毒素血症的代谢特征似乎非常不利，涉及多种炎症特征和心脏代谢疾病的危险因素。