SRY-box transcription factor 2 (SOX2) overlapping transcript (SOX2-OT) is an evolutionarily conserved long noncoding RNA. Its intronic region contains the SOX2 gene, the major regulator of the pluripotency of embryonic stem cells. The human SOX2-OT gene comprises multiple exons and has multiple transcription start sites and generates hundreds of transcripts. Transcription factors (IRF4, AR, and SOX3), transcriptional inhibitors (NSPc1, MTA3, and YY1), and miRNAs (miR-211 and miR-375) have been demonstrated to control certain SOX2-OT transcript level at the transcriptional or posttranscriptional levels. Accumulated evidence indicates its crucial roles in the regulation of the SOX2 gene, miRNAs, and transcriptional process. Restricted expression of SOX2-OT transcripts in the brain results in the association between SOX2-OT single nucleotide polymorphisms and mental illnesses such as schizophrenia and anorexia nervosa. SOX2-OT is notably elevated in tumor tissues, and a high level of SOX2-OT is well correlated with poor clinical outcomes in cancer patients, leading to the establishment of its role as an oncogene and a prognostic or diagnostic biomarker for cancers. The emerging evidence supports that SOX2-OT mediates diabetic complications. In summary, SOX2-OT has diversified functions and could be a therapeutic target for various diseases.

中文翻译：

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长非编码RNA SOX2-OT：调节，功能和对精神疾病，癌症和糖尿病并发症的作用。

SRY-box转录因子2（SOX2）重叠转录本（SOX2-OT）是一种进化保守的长非编码RNA。它的内含子区域包含SOX2基因，它是胚胎干细胞多能性的主要调节剂。人SOX2-OT基因包含多个外显子，具有多个转录起始位点，并产生数百个转录本。已经证明转录因子（IRF4，AR和SOX3），转录抑制剂（NSPc1，MTA3和YY1）和miRNA（miR-211和miR-375）可以​​控制某些SOX2-OT转录水平在转录或转录后水平。积累的证据表明其在调节SOX2基因，miRNA和转录过程中的关键作用。大脑中SOX2-OT转录物的表达受限导致SOX2-OT单核苷酸多态性与精神疾病（例如精神分裂症和神经性厌食症）之间的关联。SOX2-OT在肿瘤组织中显着升高，并且高水平的SOX2-OT与癌症患者的不良临床结局密切相关，从而确立了其作为癌基因和癌症预后或诊断生物标志物的作用。新兴证据支持SOX2-OT介导糖尿病并发症。总之，SOX2-OT具有多种功能，可以作为多种疾病的治疗靶标。从而确立了其作为癌基因和癌症的预后或诊断生物标志物的作用。新兴证据支持SOX2-OT介导糖尿病并发症。总之，SOX2-OT具有多种功能，可以作为多种疾病的治疗靶标。从而确立了其作为癌基因和癌症的预后或诊断生物标志物的作用。新兴证据支持SOX2-OT介导糖尿病并发症。总之，SOX2-OT具有多种功能，可以作为多种疾病的治疗靶标。