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PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition
Analytical Cellular Pathology ( IF 3.2 ) Pub Date : 2020-11-27 , DOI: 10.1155/2020/8396023
Hui Xiao 1 , Longxiao Zhang 2 , Yuan Chen 1 , Chengjun Zhou 1 , Xiao Wang 1 , Dehai Wang 1 , Zhenzhong Liu 1
Affiliation  

Breast cancer is the leading cause of females characterized by high invasive potential. It is necessary to explore the underlying mechanism of breast cancer metastases and to find specific therapeutic targets. PKM2 is considered a new biomarker of cancer with upregulated expression in tumor tissue. PKM2 participates in the cancer-specific Warburg effect to regulate fast glucose intake consumption. Besides, PKM2 also contributes to cancer progression, especially tumor metastasis. In this study, we showed that PKM2 is upregulated in breast cancer tissues and the upregulating of PKM2 in breast cancer correlates with poor prognosis. PKM2 can regulate tumor progression by promoting tumor cell viability and mobility. Furthermore, overexpression of PKM2 can promote EMT to encourage tumor metastasis. These findings indicate PKM2 is a potentially useful diagnostic biomarker and therapeutic target in breast cancer.

中文翻译:

PKM2 通过调节上皮间充质转化促进乳腺癌进展

乳腺癌是女性的主要原因,其特点是具有高侵袭潜力。有必要探索乳腺癌转移的潜在机制并寻找特定的治疗靶点。PKM2 被认为是一种新的癌症生物标志物,在肿瘤组织中表达上调。PKM2 参与癌症特异性 Warburg 效应以调节快速葡萄糖摄入消耗。此外,PKM2 也有助于癌症进展,尤其是肿瘤转移。在这项研究中,我们发现 PKM2 在乳腺癌组织中上调,并且 PKM2 在乳腺癌中的上调与不良预后相关。PKM2 可以通过促进肿瘤细胞活力和移动性来调节肿瘤进展。此外,PKM2的过表达可以促进EMT以促进肿瘤转移。
更新日期:2020-11-27
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