To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s, p < 0.001, 0.08 vs. 0.09 m/s, p < 0.01 and 0.13 vs. 0.14 m/s, p = 0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s, p = 0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers.

评估杜氏营养不良（DMD）女性携带者的亚临床心功能损害。被证实为DMD携带者的44名女性受试者接受了超声心动图检查，包括二尖瓣和三尖瓣环的组织多普勒成像（TDI）。十七名年龄匹配的健康女性受试者作为对照。对于二尖瓣环的外侧和中部部分以及三尖瓣环，发现携带者和对照者之间的收缩期峰值收缩速度（Sa）的显着差异（0.09 vs. 0.11 m / s，p  <0.001、0.08 vs. 0.09 m / s ，p  <0.01和0.13 vs. 0.14 m / s，p  = 0.02）。二尖瓣环间隔部分的早期舒张速度（Ea）也存在差异（0.11 vs. 0.13 m / s，p = 0.03）。即使在无症状的DMD女性携带者中，也会出现收缩功能的亚临床恶化。