Abstract

The bimodal mesoporous silicas nanoparticles (BMMs) with small size of 20–50 nm and mesoporous silicas nanoparticles (MSNs) with large sizes from 80 nm to 280 nm were synthesized using sol–gel method. These functionalized mesoporous silicas composites with different sizes were acquired by environmental responsive (pH/temperature) copolymer coated onto the mesoporous silica hosts via the seed polymerization method. The structural features and textual parameters of resultant samples were characterized by X-ray diffraction, scanning electron microscope, transmission electron microscope, N₂ adsorption–desorption isotherms, thermogravimetric analyses, FT-IR, DLS, SAXS technologies, indicating that copolymer was successfully coated on the mesoporous silicas. Meanwhile, functionalized mesoporous silicas composites as drug carries were used to explore the pH/temperature responsive efficiency. These results showed that compared with the blank mesoporous silicas nanoparticles, mesoporous silicas composites realized a reduced initial burst release. In particular, the particle size of mesoporous silicas composites effects on the release behaviors were found that the smaller composite nanoparticles with short mesoporous channels exhibited highly pH/temperature response compared to the larger composite nanoparticles with long mesoporous channels. Meanwhile, their IBU-release kinetic profiles followed Korsmeyer–Peppas model. Moreover, the toxicity of mesoporous silicas composites was evaluated in vitro. It found that the particle size of mesoporous silicas composites was essential for its cytotoxicity.

摘要

采用溶胶-凝胶法合成了 20-50 nm 的小尺寸双峰介孔二氧化硅纳米粒子 (BMM) 和 80-280 nm 的大尺寸介孔二氧化硅纳米粒子 (MSN)。这些具有不同尺寸的功能化介孔二氧化硅复合材料是通过种子聚合方法将环境响应（pH/温度）共聚物涂覆在介孔二氧化硅主体上获得的。用X射线衍射、扫描电镜、透射电镜、N _{2对所得样品的结构特征和文本参数进行了表征}吸附-解吸等温线、热重分析、FT-IR、DLS、SAXS 技术表明共聚物成功地包覆在介孔二氧化硅上。同时，功能化的介孔二氧化硅复合材料作为药物载体被用来探索pH/温度响应效率。这些结果表明，与空白介孔二氧化硅纳米粒子相比，介孔二氧化硅复合材料实现了降低的初始突释。特别是，介孔二氧化硅复合材料的粒径对释放行为的影响发现，与具有长介孔通道的较大复合纳米颗粒相比，具有短介孔通道的较小复合纳米颗粒表现出较高的pH/温度响应。同时，他们的 IBU 释放动力学曲线遵循 Korsmeyer-Peppas 模型。而且，体外。研究发现介孔二氧化硅复合材料的粒径对其细胞毒性至关重要。