Modulation of glutamatergic neurotransmission in schizophrenia by sarcosine leads to a reduction in primary negative symptoms, while its metabolic profile is safe. In order to extend research in the area, we assessed serum levels of neuropeptide Y (NPY), a hypothalamic hormone related to anxiety and depression, also involved in mechanisms inducing weight gain. Additionally, we analyzed associations between NPY concentrations and its changes with severity of symptoms and metabolic parameters.

中文翻译：

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肌氨酸增强治疗期间慢性精神分裂症患者的血清神经肽 Y 水平（双盲随机对照 PULSAR 研究的结果）

肌氨酸对精神分裂症中谷氨酸能神经传递的调节导致原发性阴性症状减少，而其代谢特征是安全的。为了扩大该领域的研究，我们评估了神经肽 Y (NPY) 的血清水平，这是一种与焦虑和抑郁相关的下丘脑激素，也参与导致体重增加的机制。此外，我们分析了 NPY 浓度及其变化与症状严重程度和代谢参数之间的关联。