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Synthesis and Biological Evaluation of New 4,5,6,7‐Tetrahydro‐1H‐imidazo[4,5‐c]pyridine Derivatives
ChemistrySelect ( IF 2.1 ) Pub Date : 2020-11-27 , DOI: 10.1002/slct.202003440
Mikhail A. Prezent 1 , Sergey V. Baranin 1
Affiliation  

A number of new spinaceamine derivatives have been synthesized by the Suzuki reaction of 5‐Boc‐2‐iodo‐spinaciamine with aryl or heteryl boronic acids. The obtained compounds exhibited a varying degree of ABTS radical‐scavenging activity, and some of them found to be more effective radical‐scavengers comparing with spinacine. Both spinacine and its synthesized derivatives do not inhibit cholinesterases and carboxylesterase.

中文翻译:

新型4,5,6,7-四氢-1H-咪唑并[4,5-c]吡啶衍生物的合成及生物评价

5‐Boc‐2‐碘‐斯皮纳西胺与芳基或杂基硼酸的Suzuki反应合成了许多新的Spinaceamine衍生物。所获得的化合物表现出不同程度的ABTS自由基清除活性,其中一些化合物与菠菜碱相比是更有效的自由基清除剂。菠菜碱及其合成衍生物均不抑制胆碱酯酶和羧酸酯酶。
更新日期:2020-11-27
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